A portable rectal near infrared (NIR) scanning polarization imaging unit with an optical fiber-based rectal probe, designated as a Photonic Finger (PF), was designed, developed, built and tested. PF was used to image and locate the three dimensional (3D) positions of abnormal prostate tissue embedded inside normal prostate tissue. An inverse image reconstruction algorithm, namely Optical Tomography using Independent Component Analysis (OPTICA) was developed to unmix the signal from targets (cancerous tissue) embedded in a turbid media (normal tissue) in the backscattering imaging geometry. The Photonic Finger combined with OPTICA was ex vivo tested to characterize different target(s) inside different tissue medium, including cancerous prostate tissue embedded inside large pieces of normal tissue. This new developed instrument, Photonic Finger, may provide an alternative imaging technique, which is accurate, of high spatial resolution and non-or-less invasive for prostate cancers screening.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1177/153303461101000602 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
In vivo Raman spectroscopy for non-invasive transcutaneous glucose monitoring on animal models and human subjects.
Spectrochim Acta A Mol Biomol Spectrosc
December 2024
Institute of Photonics and Photon-Technology, Northwest University, Xi'an, Shaanxi 710127, China. Electronic address:
Non-invasive glucose monitoring represents a significant advancement in diabetes management and treatment as non-painful alternatives than finger-sticks tests. After developing an integrated Raman spectral system with a 785 nm laser, this study systematically explores the application of in vivo Raman spectroscopy for quantitative, noninvasive glucose monitoring. In addition to observing characteristic glucose spectral information from a mouse model, a strong spectral correlation was also recognized with the blood glucose concentration.
View Article and Find Full Text PDFPbS Quantum Dot-Based Optoelectronic Memristors toward Multi-Task Reservoir Computing.
J Phys Chem Lett
December 2024
Institute of Optoelectronic Technology, Fuzhou University, Fuzhou 350116, China.
The rise of big data and the internet of things has driven the demand for multimodal sensing and high-efficiency low-latency processing. Inspired by the human sensory system, we present a multifunctional optoelectronic-memristor-based reservoir computing (OM-RC) system by utilizing a CuSCN/PbS quantum dots (QDs) heterojunction. The OM-RC system exhibits volatile and nonlinear responses to electrical signals and wide-spectrum optical stimuli covering ultraviolet, visible, and near-infrared (NIR) regions, enabling multitask processing of dynamic signals.
View Article and Find Full Text PDFBioinspired designer DNA NanoGripper for virus sensing and potential inhibition.
Sci Robot
November 2024
Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
DNA has shown great biocompatibility, programmable mechanical properties, and precise structural addressability at the nanometer scale, rendering it a material for constructing versatile nanorobots for biomedical applications. Here, we present the design principle, synthesis, and characterization of a DNA nanorobotic hand, called DNA NanoGripper, that contains a palm and four bendable fingers as inspired by naturally evolved human hands, bird claws, and bacteriophages. Each NanoGripper finger consists of three phalanges connected by three rotatable joints that are bendable in response to the binding of other entities.
View Article and Find Full Text PDFEffects of 1267 nm Illumination on Microcirculation Regulatory Mechanisms.
J Biophotonics
November 2024
R&D Center of Biomedical Photonics, Orel State University, Orel, Russia.
This study explored the effects of 1267 nm laser irradiation on changes in blood flow parameters and activation of the regulatory mechanisms of the microcirculatory bed (MCB). Using laser Doppler flowmetry (LDF) technique and time-frequency analysis of perfusion signals, changes in the MCB of 16 healthy volunteers, targeting the distal phalanx of the third finger with 1267 nm laser irradiation were evaluated. Results indicated no significant differences in perfusion between control and target measurements, likely due to blood flow redistribution caused by vessel dilation/constriction.
View Article and Find Full Text PDFEffect of PI3-kinase inhibitors on DNA double strand break repair pathways: observations using a site specific DSB induction system.
Radiat Prot Dosimetry
November 2024
Department of Biological Sciences, Ibaraki University, Bunkyo 2-1-1, Mito 310-8512, Ibaraki, Japan.
Article Synopsis
- One system used a zinc finger nuclease to target the human HPRT1 gene for mutation assays, while the other allowed for analysis of homology-directed repair (HR) in a specific cell line.
- Our findings suggest that inhibiting ATM kinase decreases mutation frequency but increases HR frequency, indicating that ATM activity may help regulate DSB repair pathways.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!