Objective: a gap in comprehensive knowledge of trafficking in persons and the traffickers exists globally and in Tanzania in particular. Consequently, information on the profiles of human traffickers in the country is tremendously scanty.
Methods: we conducted a baseline study in eight administrative regions of Tanzania Mainland using both qualitative and quantitative methods to generate data in to inform anti-human trafficking health interventions and programs to be implemented in the country. Study participants included the national, regional and district Community Development Officers, District Medical Officers, local government leaders, managers or representatives of non-governmental organizations involved in anti-trafficking in persons activities, members of the community and victims.
Results: different individuals or groups, knowingly or ignorantly, contribute to trafficking in persons and their roles differ at the places of origin, transit and destinations. Traffickers are males or females with varied age, marital status, relationships with victims, socio-economic status, experience and occupations.
Conclusions: active traffickers at many stages of this crime rarely come into contact with the law enforcement system; fled or rescued victims may not be willing or unable to testify against their traffickers and coercing victims to do so could further traumatize them. Further research in needed to generate knowledge on human traffickers' profiles to inform trafficking in persons control programs through HIV and AIDS interventions in Tanzania.
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J Inherit Metab Dis
January 2025
Department of Neurology and MetabERN; Esplugues de Llobregat, Synaptic Metabolism and Personalized Therapies Lab, Institut de Recerca Sant Joan de Déu, Barcelona, Spain.
Cell trafficking is a tightly regulated biological process for the exchange of signals and metabolites between cell compartments, including four main processes: membrane trafficking (transport of membrane-bound vesicles), autophagy, transport along the cytoskeleton, and membrane contact sites. These processes are cross-sectional to cellular functions, ranging from the transportation of membrane proteins, membranes, and organelles to the elimination of damaged proteins and organelles. In consequence, cell trafficking is crucial for cell survival and homeostasis, serving as a cornerstone for cellular communication and facilitating interactions both with the surrounding environment and between different organelles.
View Article and Find Full Text PDFJ Mol Biol
January 2025
Elettra Sincrotrone Trieste, Italy; The Wohl Institute, King's College London, 5 Cutcombe Rd, SW59RT London, UK. Electronic address:
Annexins are a family of calcium-dependent phospholipid-binding proteins involved in crucial cellular processes such as cell division, calcium signaling, vesicle trafficking, membrane repair, and apoptosis. In addition to these properties, Annexins have also been shown to bind RNA, although this function is not universally recognized. In the attempt to clarify this important issue, we employed an integrated combination of experimental and computational approaches.
View Article and Find Full Text PDFBiochim Biophys Acta Mol Cell Res
January 2025
CSIR-Centre for Cellular and Molecular Biology, Hyderabad 500007, India; Florida Research and Innovation Center, Cleveland Clinic, Port Saint Lucie, FL 34987, USA. Electronic address:
Optineurin/OPTN is an adapter protein that plays a crucial role in mediating many cellular functions, including autophagy, vesicle trafficking, and various signalling pathways. Mutations of OPTN are linked with neurodegenerative disorders, glaucoma, and amyotrophic lateral sclerosis (ALS). Recent work has shown that OPTN provides cytoprotection from many types of stress, including oxidative stress, endoplasmic reticulum stress, protein homeostasis stress, tumour necrosis factor α, and microbial infection.
View Article and Find Full Text PDFBiomed Pharmacother
January 2025
Department of Experimental Medicine, Sapienza University of Rome, Rome 00161, Italy. Electronic address:
The abundance and behaviour of all hematopoietic components display daily oscillations, supporting the involvement of circadian clock mechanisms. The daily variations of immune cell functions, such as trafficking between blood and tissues, differentiation, proliferation, and effector capabilities are regulated by complex intrinsic (cell-based) and extrinsic (neuro-hormonal, organism-based) mechanisms. While the role of the transcriptional/translational molecular machinery, driven by a set of well-conserved genes (Clock genes), in nucleated immune cells is increasingly recognized and understood, the presence of non-transcriptional mechanisms remains almost entirely unexplored.
View Article and Find Full Text PDFEur J Cell Biol
December 2024
Université de Reims Champagne-Ardenne, INSERM, P3Cell, UMR-S 1250, Reims, France. Electronic address:
The tumor suppressor fragile histidine triad (FHIT) is frequently lost in non-small cell lung cancer (NSCLC). We previously showed that a down-regulation of FHIT causes an up-regulation of the activity of HER2 associated to an epithelial-mesenchymal transition (EMT) and that lung tumor cells harboring a FHIT/pHER2 phenotype are sensitive to anti-HER2 drugs. Here, we sought to decipher the FHIT-regulated HER2 signaling pathway in NSCLC.
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