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LEGO-Lipophosphonoxin membrane activity is enhanced by presence of phosphatidylethanolamine but hindered by outer membrane.
Sci Rep
January 2025
Department of Genetics and Microbiology, Faculty of Science, Charles University, Viničná 5, 128 00, Prague, Czech Republic.
Finding effective antibiotics against multi-resistant strains of bacteria has been a challenging race. Linker-Evolved-Group-Optimized-Lipophosphonoxins (LEGO-LPPOs) are small modular synthetic antibacterial compounds targeting the cytoplasmic membrane. Here we focused on understanding the reasons for the variable efficacy of selected LEGO-LPPOs (LEGO-1, LEGO-2, LEGO-3, and LEGO-4) differing in hydrophobic and linker module structure and length.
View Article and Find Full Text PDFESBL- and pAmpC-producing Enterobacterales from Swedish dogs and cats 2017-2021: a retrospective study.
Acta Vet Scand
January 2025
Department of Animal Health and Antibiotic Strategies, Swedish Veterinary Agency, Uppsala, Sweden.
Background: Antibiotic resistant bacteria are a threat to both human and animal health. Of special concern are resistance mechanisms that are transmissible between bacteria, such as extended-spectrum beta-lactamases (ESBL) and plasmid-mediated AmpC (pAmpC). ESBL/AmpC resistance is also of importance as it confers resistance to beta-lactam antibiotics including third generation cephalosporins.
View Article and Find Full Text PDFComparison of X-Ray Attenuation Performance, Antimicrobial Properties, and Cytotoxicity of Silicone-Based Matrices Containing BiO, PbO, or BiO/PbO Nanoparticles.
J Biomed Phys Eng
December 2024
Department of Radiology, Faculty of Allied Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.
Background: Application of the nanomaterials to preparing X-ray shields and successfully treating multiresistant microorganisms has attracted great attention in modern life.
Objective: This study aimed to prepare flexible silicone-based matrices containing BiO, PbO, or BiO/PbO nanoparticles and select a cost-effective, cytocompatible, and antibacterial/antifungal X-ray shield in clinical radiography.
Material And Methods: In this experimental study, we prepared the nanoparticles by the modified biosynthesis method and fabricated the X-ray shields containing 20 wt% of the nanoparticles.
Epidemiological investigation and drug resistance analysis of avian pathogenic (APEC) of Wenchang chickens in Hainan, China.
Avian Pathol
January 2025
The Sanya Institute of Nanjing Agricultural University, Yabulun Industrial Park, Yazhou Bay Science and Technology City, Sanya, People's Republic of China.
Type O8 is the most prevalent serotype of APEC isolated from Wenchang chicken embryos (Hainan, China).The isolates were more than 90% resistant to erythromycin, amoxicillin, ampicillin, and tetracycline.19.
View Article and Find Full Text PDFAvian Pathogenic Isolated in Poultry Farms in Bangladesh that Use Antibiotics Extensively.
Microb Drug Resist
November 2024
Agribio, Agriculture Victoria Research, Bundoora, Australia.
Colibacillosis caused by avian pathogenic (APEC) is causing economic losses to the global poultry industry. Increased prevalence of antibiotic resistance in APEC is the leading cause for increased indiscriminate use of various antimicrobial compounds in farms. The study aimed to investigate the presence of phenotypic and genotypic markers for antibiotic resistance, metals, and biocides in APEC from Bangladeshi poultry and details about the antimicrobials used in poultry farms.
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