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Petrous Bone Cholesteatoma- A Comprehensive Management Algorithm and Outcomes.
Indian J Otolaryngol Head Neck Surg
January 2025
Department of Otorhinolaryngology, All India Institute of Medical Sciences, Jodhpur Mobile No: + 91, Jodhpur, 8547956262 India.
Unlabelled: Background: Petrous bone cholesteatoma (PBC) is a challenging condition involving the development of an epidermoid cyst within the petrous portion of the temporal bone. Advances in radiological imaging and skull base surgery have refined the management of PBC. Methods: An ambispective descriptive study was conducted on patients diagnosed with PBC between 2021 and 2024.
View Article and Find Full Text PDFis a Major Prognostic Biomarker for Relapse in Childhood B-cell Acute Lymphoblastic Leukemia: A National Study of Unselected Cohort.
Balkan J Med Genet
December 2024
Center for Biomolecular Pharmaceutical Analyses, Faculty of Pharmacy, University Ss. Cyril and Methodius in Skopje, Mother Theresa 47, 1000 Skopje, N. Macedonia.
Although the identification of disease subtypes conveying prognostic significance along with minimal residual disease (MRD) assessment represent cornerstones for stratification in childhood acute lymphoblastic leukemia (ALL), approximately half of the relapses occur in patients from standard-risk groups. Identification of the drivers of treatment failure is crucial for detection of high-risk clones at diagnosis. We evaluated clinical variables and the most common genetic alterations in an unselected cohort of 55 patients with B-ALL treated according to the ALL-IC-BFM 2002 protocol, with a median follow-up of 46 months.
View Article and Find Full Text PDFLong-term benefit of afatinib combined with bevacizumab in a lung adenocarcinoma patient with a novel rare EGFR Q787L mutation.
Int Immunopharmacol
March 2025
Department of Pulmonary and Clinical Care Medicine, The First Affiliated Hospital of Guangxi Medical University, No.6 Shuangyong Road, Nanning City 530021, PR China. Electronic address:
Background: The epidermal growth factor receptor (EGFR) is among the most frequently mutated genes in lung adenocarcinomas (LUAC). The combination of afatinib and bevacizumab has primarily been reported in LUAC cases exhibiting resistance to EGFR tyrosine kinase inhibitors (EGFR-TKI), particularly in classical variants such as EGFR exon 19 deletions and the L858R mutation in exon 21. However, the clinical efficacy of afatinib combined with bevacizumab in treating rare EGFR mutations remains underexplored.
View Article and Find Full Text PDFInhibitor Eradication in Postpartum Acquired Haemophilia A: Real-Life Case Series and Literature Review.
Haemophilia
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Division of Hematology and Bone Marrow Transplantation, Azienda Ospedaliero-Universitaria Policlinico G. Rodolico - San Marco, Catania, Italy.
Background: Acquired haemophilia A (AHA) is a rare and severe bleeding disorder generally associated with pregnancy or aging. Spontaneous remission and prompt inhibitor eradication are described more frequently in postpartum cases. We evaluated retrospectively 15 postpartum AHA cases between 2007 and 2023 in order to evaluate response in terms of inhibitor eradication.
View Article and Find Full Text PDFLeukemia confers a durable imprint on healthy hematopoietic stem and progenitor cells.
Cancer Lett
February 2025
Comprehensive Bone Marrow Failure Center, Division of Hematology, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA, USA; Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. Electronic address:
Recent models of infection and experimental inflammation reveal that hematopoietic stem and progenitor cells (HSPCs) can generate a memory of the exposure. While the acute inflammatory activity rapidly resolves, cells acquire a heightened capacity to respond to subsequent stimulation. Inflammation is also a constitutive feature of cancer, including hematologic malignancies.
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