AI Article Synopsis
- Accurate focusing in whole slide imaging is challenging due to the variability in tissue topography, making it difficult for traditional scanning systems to maintain focus while processing images quickly.
- This review discusses the shortcomings of first-generation whole slide scanners and introduces a new method called independent dual sensor scanning, which uses continuous autofocus.
- The new approach separates image acquisition from focusing, enabling faster scanning with better focus accuracy, and the paper also examines the pros and cons of this technique compared to traditional systems.
Article Abstract
Accurate focusing is a critical challenge of whole slide imaging, primarily due to inherent tissue topography variability. Traditional line scanning and tile-based scanning systems are limited in their ability to acquire a high degree of focus points while still maintaining high throughput. This review examines limitations with first-generation whole slide scanning systems and explores a novel approach that employs continuous autofocus, referred to as independent dual sensor scanning. This "second-generation" concept decouples image acquisition from focusing, allowing for rapid scanning while maintaining continuous accurate focus. The technical concepts, merits, and limitations of this method are explained and compared to that of a traditional whole slide scanning system.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3205523 | PMC |
| http://dx.doi.org/10.4103/2153-3539.86282 | DOI Listing |
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