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Assessing the inflammatory response to in vitro polymicrobial wound biofilms in a skin epidermis model.
NPJ Biofilms Microbiomes
April 2022
Oral Sciences Research Group, Glasgow Dental School, School of Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, G12 8TA, UK.
Wounds can commonly become infected with polymicrobial biofilms containing bacterial and fungal microorganisms. Microbial colonization of the wound can interfere with sufficient healing and repair, leading to high rates of chronicity in certain individuals, which can have a huge socioeconomic burden worldwide. One route for alleviating biofilm formation in chronic wounds is sufficient treatment of the infected area with topical wound washes and ointments.
View Article and Find Full Text PDFUnusual case of hyperemesis in a pregnant patient with prior antireflux surgery.
BMJ Case Rep
August 2021
General Surgery, University Hospitals Coventry and Warwickshire NHS Trust, Coventry, UK.
A 33-year-old, 8 weeks pregnant, presented with severe upper abdominal pain with vomiting on a background of a previous laparoscopic Nissen fundoplication for reflux disease. An urgent MRI had shown herniation of the fundoplication wrap through the diaphragmatic hiatus. The cause of her symptoms was attributed to hyperemesis gravidarum.
View Article and Find Full Text PDFThe Human Gut Phageome: Origins and Roles in the Human Gut Microbiome.
Front Cell Infect Microbiol
July 2021
School of Life Sciences, The University of Warwick, Coventry, United Kingdom.
The investigation of the microbial populations of the human body, known as the microbiome, has led to a revolutionary field of science, and understanding of its impacts on human development and health. The majority of microbiome research to date has focussed on bacteria and other kingdoms of life, such as fungi. Trailing behind these is the interrogation of the gut viruses, specifically the phageome.
View Article and Find Full Text PDFIsolation and Characterization of Phages for Phage Therapy.
Phage (New Rochelle)
March 2021
Department of Microbiology and Virology, School of Life Sciences, Gibbet Hill Campus, The University of Warwick, Coventry, United Kingdom.
is a clinically important pathogen causing a variety of antimicrobial resistant infections in both community and nosocomial settings, particularly pneumonia, urinary tract infection, and sepsis. Bacteriophage (phage) therapy is being considered a primary option for the treatment of drug-resistant infections of these types. We report the successful isolation and characterization of 30 novel, genetically diverse phages.
View Article and Find Full Text PDFCAUTI's next top model - Model dependent biofilm inhibition by bacteriophages and antimicrobials.
Biofilm
December 2020
School of Life Sciences, Gibbet Hill Campus, The University of Warwick, Coventry CV4 7AL, United Kingdom.
infections, including catheter associated urinary tract infections, are a considerable burden on health care systems. This is due to their difficulty to treat, caused by antimicrobial resistance and their ability to form biofilms. In this study, we investigated the use of a phage cocktail to reduce biofilm viability.
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