Brown seaweeds are popular and abundant food in East Asia and also well known for their medicinal effects due to presence of active phenolic constituents. Phlorotannins, the major phenolic group of brown algae, have extensively investigated for their vast array of bioactivities such as antioxidant, anti-inflammatory, anticancer, and antidiabetic. They possess promising activity in both in vitro and in vivo systems showing promising potential to further develop as therapeutic agents. In this chapter, attempts have taken to examine and categorize the reports available on active phlorotannins which have shown strong bioactivities.
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