AI Article Synopsis
- The case involves a 76-year-old man with a history of smoking who has been diagnosed with combined pulmonary fibrosis and emphysema, leading to pulmonary hypertension and worsening heart failure.
- Treatment with a combination of sitaxsentan and sildenafil led to significant improvements in his health and exercise capacity, without any major side effects.
- Combined pulmonary fibrosis and emphysema is a relatively new syndrome linked to smoking, marked by specific lung damage patterns, low oxygen levels, and is notably associated with severe shortness of breath; effective treatment studies in these patients are currently lacking.
Article Abstract
We describe a 76-year-old former smoker with a diagnosis of combined pulmonary fibrosis and emphysema associated with pulmonary hypertension and rapidly progressive right heart failure, in whom combined treatment with sitaxsentan and sildenafil resulted in sustained improvement of his clinical condition and exercise performance, without any relevant adverse events. Combined pulmonary fibrosis and emphysema comprises a recently identified syndrome, probably related to tobacco use, and characterized by the coexistence of upper-lobe emphysema and fibrotic changes of the lower lobes, preserved lung volumes, significant hypoxemia, and a high prevalence of pulmonary hypertension, resulting in severe dyspnea. To date, no prospective series, to the best of our knowledge, has reported on the effects of pulmonary vasodilator therapy in such patients.
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| http://dx.doi.org/10.1016/j.hrtlng.2011.09.005 | DOI Listing |
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