Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3206538 | PMC |
| http://dx.doi.org/10.4081/pr.2011.s2.e13 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Article Synopsis
- γδ T-cells play a crucial role in immune surveillance following HLA-Haploidentical Stem Cell Transplantation (haplo-HSCT), especially in pediatric patients.
- A study showed that a specific subset of Vδ2 T-cells is associated with better antiviral protection, as these cells were more prevalent in patients who did not experience viral reactivation.
- The research highlights how Vδ2 T-cells can inhibit CMV replication and enhance the immune response, suggesting their potential use in immunotherapy post-transplantation to combat both infections and tumors.
HLA-haploidentical T-cell receptor αβT/B-cell-depleted stem cell transplantation for Fanconi anemia.
Int J Hematol
March 2024
Children's Cancer Center, National Center for Child Health and Development, 2-10-1 Okura, Setagaya-ku, Tokyo, 157-8535, Japan.
Article Synopsis
- HLA-haploidentical stem cell transplantation (haplo-SCT) using post-transplant high-dose cyclophosphamide (PT-CY) is typically an alternative for patients without suitable donors, but it's risky for those with Fanconi anemia (FA).
- For FA patients, αβT-cell and B-cell depletion (αβT/B-depleted haplo-SCT) is preferred to lower the chances of complications from PT-CY and graft-versus-host disease (GVHD).
- In a case study, an 11-year-old boy with FA successfully received αβT/B-depleted haplo-SCT from his father, achieving neutrophil engraftment by day 9 and remaining healthy without GV
How adoptive transfer of components of the donor immune system boosts GvL and prevents GvHD in HLA-haploidentical hematopoietic transplantation for acute leukemia.
Bone Marrow Transplant
March 2024
Department of Medicine and Surgery, Division of Hematology and Clinical Immunology, University of Perugia, Perugia, Italy.
Why a new Perspective in allogeneic hematopoietic transplantation? A summary. Nowadays, for high-risk acute leukemia patients without an HLA-matched donor (sibling or volunteer), hematopoietic transplants that use HLA-haploidentical grafts combined with enhanced post transplant immune suppression (i.e.
View Article and Find Full Text PDFTCRαβ/CD19 cell-depleted HLA-haploidentical transplantation to treat pediatric acute leukemia: updated final analysis.
Blood
January 2024
Department of Pediatric Hematology/Oncology, Cell and Gene Therapy, Istituto di Ricovero e Cura a Carattere Scientifico Bambino Gesù Children's Hospital, Rome, Italy.
TCRαβ/CD19 cell depletion is a promising graft manipulation technique frequently used in the context of human leukocyte antigen (HLA)-haploidentical hematopoietic stem cell transplantation (HSCT). We previously reported the results of a phase I-II clinical trial (NCT01810120) to assess the safety and the efficacy of this type of exvivo T-cell depletion in 80 children with acute leukemia, showing promising survival outcomes. We now report an updated analysis on a cohort of 213 children with a longer follow-up (median, 47.
View Article and Find Full Text PDFαβT- and B-cell-depleted HLA-haploidentical hematopoietic stem cell transplantation in children with myelodysplastic syndromes.
Haematologica
December 2022
Department of Pediatric Hematology/Oncology, Cell and Gene Therapy, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy; Sapienza, University of Rome, Rome.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!