On August 10th 2010 the World Health Organization (WHO)announced the end of the influenza A H1N1 2009 pandemic. On August 13th, three cases of influenza A H1N1 2009 from the local school were confirmed at the Hospital de Chile Chico. An epidemiological investigation was conducted in conjunction with the regional health authority (SEREMI), in order to monitor the outbreak and establish appropriate control strategies. During the study period (august 7 to 21), 304 cases of influenza-like-illness (ILI) were reported, with an incidence of 6171 cases per 100.000 in epidemiological week no 33. Most of the affected people were 19 years old or younger (68% of cases). Hospitalized patients (n: 7) had a favorable outcome, without severe symptoms or need for transfer to an intensive care unit. A female patient with a congenital heart defect who had not been vaccinated was the only fatal case. The outstanding features of this post-pandemic outbreak were its intensity and the demonstration of the importance of control measures to prevent further spread of influenza A H1N1 2009 infections, in the community setting.
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EClinicalMedicine
January 2025
Janssen Research and Development, Beerse, Belgium.
Background: Vaccine co-administration can increase vaccination coverage. We assessed the safety, reactogenicity, and immunogenicity of concomitant administration of Ad26.COV2.
View Article and Find Full Text PDFIJID Reg
March 2025
Postgraduate Program in Parasitic Biology, Federal University of Sergipe, Sergipe, Brazil.
Objectives: To investigate the prevalence of nine respiratory viruses and their clinical characteristics in children aged up to 5 years old in the state of Sergipe, Northeast of Brazil in the pre-COVID-19 pandemic period.
Methods: Children with suspected influenza virus infection were included in the study. Clinical samples were screened using real-time quantitative polymerase chain reaction for the diagnosis of adenovirus, parainfluenza (PIV)1, PIV2, PIV3, and human metapneumovirus.
Vet Microbiol
January 2025
College of Veterinary Medicine, Jilin Provincial Engineering Research Center of Animal Probiotics, Jilin Provincial Key Laboratory of Animal Microecology and Healthy Breeding, Engineering Research Center of Microecological Vaccines (Drugs) for Major Animal Diseases, Ministry of Education, Jilin Agricultural University, Changchun 130118, China. Electronic address:
Swine influenza virus invades the host through the respiratory mucosa, which severely restricts the development of the pig breeding industry. To construct monomeric and trimeric vaccines, we developed recombinant Escherichia coli Nissle 1917 (EcN) strains that express the receptor binding site (RBS) of the hemagglutinin (HA) antigen from H1N1 swine influenza virus. After the mucosal immunization of mice, we found that probiotics activated CD40 and CD86 in DCs and increased the levels of IL-4 and IFN-γ secretion by T cells.
View Article and Find Full Text PDFAcute respiratory infections (ARIs) are a leading cause of death in children under five globally. The seasonal trends and profiles of respiratory viruses vary by region and season. Due to limited information and the population's vulnerability, we conducted the hospital-based surveillance of respiratory viruses in Eastern Uttar Pradesh.
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December 2024
Shanghai Veterinary Research Institute, 518 Ziyue Road, Minhang District, Shanghai 200241, China.
During the life cycle of the influenza virus, viral RNPs (vRNPs) are transported to the nucleus for replication. Given that a large number of progeny viral RNA occupies the nucleus, whether there is any host protein located in the nucleus that recognizes the viral RNA and inhibits the viral replication remains largely unknown. In this study, to explore the role of hnRNPH1 in influenza virus infection, we knocked down and over-expressed the hnRNPH1 proteins in 293T cells, then infected the cells with the influenza virus.
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