New triterpenoid saponins from Patrinia scabiosaefolia.

Carbohydr Res

College of Pharmaceutical Science, Soochow University, Suzhou 215123, Jiangsu Province, China.

Published: December 2011

Phytochemical investigation of the methanol extract from the whole plants of Patrinia scabiosaefolia Fisch. resulted in the isolation of four new triterpenoid saponins (1-4) along with six known compounds (5-10). On the basis of spectroscopic and chemical methods, the structures of the new compounds were established as 3-O-β-D-xylopyranosyl-(1→3)-α-L-rhamnopyranosyl-(1→2)-β-D-xylopyranosyl-12β,30-dihydroxy-olean-28,13β-olide (1), 3-O-α-L-rhamnopyranosyl-(1→2)-β-D-xylopyranosyl-12β,30-dihydroxy-olean-28,13β-olide (2), 3-O-β-D-xylopyranosyl-(1→2)-β-D-glucopyranosyl-12β, 30-dihydroxy-olean-28,13β-olide (3), and 3-O-β-D-glucopyranosyl-(1→4)-β-D-xylopyranosyl-(1→3)-α-L-rhamnopyranosyl-(1→2)-β-D-xylopyranosyl-oleanolic acid 28-O-β-D-glucopyranoside (4), respectively. Compounds 1-3 possess a novel 12β,30-dihydroxy-olean-28,13β-lactone aglycone and a 12β-hydroxy substituent that is rarely found in this kind of triterpenoid saponin.

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http://dx.doi.org/10.1016/j.carres.2011.10.008DOI Listing

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