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Polymorphisms in the gene are associated with the plasma levels of MBL and the cytokines IL-6 and TNF-α in severe COVID-19.
Front Immunol
May 2023
Laboratory of Virology, Institute of Biological Sciences, Federal University of Pará (UFPA), Belém, Brazil.
Introduction: Mannose-binding lectin (MBL) promotes opsonization, favoring phagocytosis and activation of the complement system in response to different microorganisms, and may influence the synthesis of inflammatory cytokines. This study investigated the association of MBL2 gene polymorphisms with the plasma levels of MBL and inflammatory cytokines in COVID-19.
Methods: Blood samples from 385 individuals (208 with acute COVID-19 and 117 post-COVID-19) were subjected to real-time PCR genotyping.
Importance of mannose-binding lectin2 polymorphism () in infections in children.
Biomarkers
February 2022
Department of Department of Hematology, University of Health Science, Istanbul Training and Research Hospital, Istanbul, Turkey.
Purpose: Mannose-binding lectin (MBL) is a serine protease belonging to the collectins and an important factor in the inherited immune system. We aimed to reveal the distribution of different genotypes in patients diagnosed with acute bronchiolitis and pneumonia.
Material And Methods: A total of 147 patients who applied to Paediatric Emergency between 01.
Associations of ficolins and mannose-binding lectin with acute myeloid leukaemia in adults.
Sci Rep
June 2020
Laboratory of Immunobiology of Infections, Institute of Medical Biology, Polish Academy of Sciences, Lodowa 106, 93-232, Lodz, Poland.
Article Synopsis
- Researchers studied the levels of ficolins and mannose-binding lectin (MBL) in 157 patients with acute myeloid leukaemia (AML) compared to 267 healthy individuals.
- They found that ficolin-1 was significantly lower in AML patients, while ficolin-2, ficolin-3, and MBL were higher, with the highest MBL levels linked to a greater risk of severe infections.
- Genotyping suggested a specific genetic variant (G/G homozygosity) associated with the disease, and ficolins could serve as potential new biomarkers for diagnosing AML and distinguishing it from other blood cancers.
Exploring association between MBL2 gene polymorphisms and the occurrence of clinical blackwater fever through a case-control study in Congolese children.
Malar J
January 2020
Department of Immunogenetics, Institute of Tropical Medicine (Nekken), University of Nagasaki, Nagasaki, Japan.
Background: Blackwater fever (BWF), one of the most severe and life-threatening forms of falciparum malaria, is characterized by acute massive intravascular haemolysis, often leading to acute renal failure. Thus far, the genetics of the underlying susceptibility to develop BWF is not fully elucidated. Deficiency in the MBL protein, an important component of the innate immune system, has previously been suggested to be a susceptibility factor for the development of severe malaria.
View Article and Find Full Text PDFAssociation between MBL2 haplotypes and dengue severity in children from Rio de Janeiro, Brazil.
Mem Inst Oswaldo Cruz
June 2019
Universidade Federal do Rio de Janeiro, Instituto de Biologia, Departamento de Genética, Laboratório de Virologia Molecular, Rio de Janeiro, RJ, Brasil.
Background: Dengue is an arthropod-borne viral disease with a majority of asymptomatic individuals and clinical manifestations varying from mild fever to severe and potentially lethal forms. An increasing number of genetic studies have outlined the association between host genetic variations and dengue severity. Genes associated to viral recognition and entry, as well as those encoding mediators of the immune response against infection are strong candidates for association studies.
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