AI Article Synopsis
- The study highlights how HIV(+) patients exhibit abnormal morphological changes in peripheral lymphocytes, leading to disrupted cell cycle and impaired immune function.
- These changes result in a high rate of circulating T cells that are likely to undergo spontaneous cell death, as indicated by damaged nuclear components and impaired energy production mechanisms.
- The damage to these cells correlates with their frequency of exiting lymphoid tissue, suggesting a connection between cellular health and the efficiency of immune clearance processes.
Article Abstract
Regressive morphological lesions, found in peripheral lymphocytes from HIV(+) patients, clearly conflict with normal cycle progression and with the execution of basic housekeeping and immune functions. With these lesions, circulating lymphocytes are destined to spontaneous and energy-independent cell lysis. By means of confocal microscopy and morphometry, we have quantified the rate of circulating T cells that are probably destined to emocatheresis in vivo. This rate includes lymphocytes in which nucleolin fragments have been scattered out of the nuclear region as a result of prelethal alterations in the nuclear membrane permeability. In terms of bioenergetics, these cells show evident anomalies in the energy production machinery that make them unable to carry out ATP-requiring functions. The extent of damaged cell fraction in peripheral blood reflects the frequency with which T lymphocytes leave lymphoid tissue to be cleared in hemocatheretic processes.
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| http://dx.doi.org/10.1089/AID.2011.0197 | DOI Listing |
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