AI Article Synopsis
- The study focuses on the creation of new nickel(II) complexes using specific chelating ligands (a, b, and c) that form solid complexes with nickel.* -
- Two of these complexes were analyzed using X-ray diffraction to determine their crystal and molecular structures, while thermal stability was assessed using TG/DTG and DSC methods.* -
- The cytotoxic potential of all complexes was tested against several cancer cell lines, with ligand c showing notably high effectiveness, surpassing the effectiveness of cisplatin against melanoma cells.*
Article Abstract
Here we present the synthesis of the new Ni(II) complexes with chelating ligands 1-benzothiazol-2-yl-3,5-dimethyl-1H-pyrazole (a), 5-(2-hydroxyphenyl)-3-methyl-1-(2-pyridylo)-1H-pyrazole-4-carboxylic acid methyl ester (b) and 1-benzothiazol-2-yl-5-(2-hydroxyphenyl)-3-methyl-1H-pyrazole-4-carboxylic acid methyl ester (c). These ligands a-c create solid complexes with Ni(II). The crystal and molecular structures of two complexes were determined by X-ray diffraction method. Thermal stability of two complexes with ligand c by TG/DTG and DSC methods were also shown. Cytotoxic activity of all the complexes against three tumour cell lines and to normal endothelial cells (HUVEC) was also estimated. Complexes with ligand c exhibited relatively high cytotoxic activity towards HL-60 and NALM-6 leukaemia cells and WM-115 melanoma cells. Cytotoxic effectiveness of one of these complexes against melanoma WM-115 cells was two times higher than that of cisplatin. The protonation constant log K=9.63 of ligand b corresponding to the phenol 2-hydroxy group has been determined in 10% (v/v) DMSO/water solution (25°C). The coordination modes (formation of two monomeric species: NiL and NiL(2)) in the complexes with Ni(II) are discussed for b on the basis of the potentiometric and UV/Vis data.
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| http://dx.doi.org/10.1016/j.ejmech.2011.10.001 | DOI Listing |
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