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Hormone circuit explains why most HPA drugs fail for mood disorders and predicts the few that work.
Mol Syst Biol
January 2025
Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, 76100, Israel.
Elevated cortisol in chronic stress and mood disorders causes morbidity including metabolic and cardiovascular diseases. There is therefore interest in developing drugs that lower cortisol by targeting its endocrine pathway, the hypothalamic-pituitary-adrenal (HPA) axis. However, several promising HPA-modulating drugs have failed to reduce long-term cortisol in mood disorders, despite effectiveness in other hypercortisolism conditions such as Cushing's syndrome.
View Article and Find Full Text PDFPredicting construction waste in Egyptian residential projects: a robust multiple regression model approach.
Sci Rep
January 2025
Construction Engineering and Utilities Department, Faculty of Engineering, Zagazig University, Zagazig, 44519, Egypt.
Effective construction waste (CW) management, mainly concrete, brick, and steel, is a critical challenge due to its significant environmental and economic impacts. This study addresses this challenge by proposing multiple linear regression models to predict waste generation in residential buildings within the Egyptian construction industry, considering the influence of factors such as building design and site management features. Using data from 25 case studies, the models demonstrated high predictive accuracy, with adjusted R² values of 0.
View Article and Find Full Text PDFMulticooperation of Turtle-inspired amphibious spherical robots.
Sci Rep
January 2025
Electrical and Information Engineering College, Jilin Agricultural Science and Technology University, Jilin, 132109, China.
It is challenging to achieve high-speed and accurate multicooperation of turtle-inspired amphibious spherical robots (ASRs) in turbid water and confined spaces when the robots are underwater movement with multiple degrees of freedom (MDOF). This paper innovatively proposes a control strategy for modelling and experimental platforms that can communicate and cooperate between multiple robots. First, a novel underwater kinematic model using the unit quaternion (UQ) algorithm is proposed based on attitude interpolation to realize MDOF movement.
View Article and Find Full Text PDFUsing feedback in pooled experiments augmented with imputation for high genotyping accuracy at reduced cost.
G3 (Bethesda)
January 2025
Division of Scientific Computing, Department of Information Technolokgy, Uppsala University, SE-751 05 Uppsala, Sweden.
Conducting genomic selection in plant breeding programs can substantially speed up the development of new varieties. Genomic selection provides more reliable insights when it is based on dense marker data, in which the rare variants can be particularly informative. Despite the availability of new technologies, the cost of large-scale genotyping remains a major limitation to the implementation of genomic selection.
View Article and Find Full Text PDFPerceptual learning of modulation filtered speech.
J Exp Psychol Hum Percept Perform
January 2025
School of Psychology, University of Sussex.
Human listeners have a remarkable capacity to adapt to severe distortions of the speech signal. Previous work indicates that perceptual learning of degraded speech reflects changes to sublexical representations, though the precise format of these representations has not yet been established. Inspired by the neurophysiology of auditory cortex, we hypothesized that perceptual learning involves changes to perceptual representations that are tuned to acoustic modulations of the speech signal.
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