Ugi post-condensation copper-triggered oxidative cascade towards pyrazoles.

Beilstein J Org Chem

Laboratoire Chimie et Procédés, Laboratoire Chimie et procédés, UMR 7652-DCSO-CNRS- ENSTA-École Polytechnique, École Nationale Supérieure de Techniques Avancées, 32 Bd Victor, Paris 75015, France.

Published: November 2011

Pyrazolidinones were prepared in a two-step sequence starting from α-hydrazonocarboxylic acids. After a four-component Ugi coupling, the resulting hydrazone was engaged in a copper triggered [3 + 2] cycloaddition/aerobic oxidation cascade.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3201043PMC
http://dx.doi.org/10.3762/bjoc.7.153DOI Listing

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