Two new Zn(II) and Cd(II) MOFs have been synthesized. These MOFs have been applied as heterogeneous catalysts for the green synthesis of a variety of dihydropyrimidinone derivatives through the Biginelli reaction and the desired products were obtained in high yields with short reaction time under mild solvent- free conditions. Moreover, the MOF catalysts may be readily recovered after the reaction and reused for many cycles.
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http://dx.doi.org/10.1016/j.tetlet.2011.09.099 | DOI Listing |
RSC Adv
December 2024
Department of Chemistry, National Institute of Technology Karnataka (NITK) Surathkal Mangalore-575025 India
3,4-Dihydropyrimidin-2(1)-ones (DHPMs) and 1,4-dihydropyridines (DHPs), prepared by applying the Biginelli and Hantzsch reaction protocols, respectively, are well-documented nitrogen-containing heterocycles with intriguing pharmacological properties. The aqueous solution of biogenic carboxylic acids renewably produced from biomass catalytic or enzymatic processes can be used as a sustainable catalyst and green reaction media for synthesizing DHPs and DHPMs. This work evaluates the efficacy of various biogenic acids in their aqueous solutions as catalysts for synthesizing DHPs and DHPMs from substituted benzaldehydes.
View Article and Find Full Text PDFBioorg Chem
November 2024
Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt.
Heliyon
October 2024
Jai Research Foundation, Valvada, Vapi, Gujarat, 396105, India.
The paper describes the construction of a new series of pyrimidinone-linked thiazole derivatives through bromination of the initial Biginelli reaction product followed by the Hantzsch thiazole synthesis route. Various analytical techniques, including FT-IR, H NMR, C NMR, and LCMS analysis, were employed to confirm the formation of the products. The synthesized compounds were primarily evaluated for their antibacterial activity, with a specific focus on their IC values.
View Article and Find Full Text PDFBioorg Chem
December 2024
Department of Science, Institute for Information Technologies Kragujevac, University of Kragujevac, Kragujevac 34000, Serbia. Electronic address:
The aim of the presented research was to explore anticancer potential of eleven newly synthesized tetrahydropyrimidine derivatives. The compounds were synthesized via Biginelli multicomponent one-pot reaction using different derivatives of vanillin, ethyl 4-chloroacetoacetate and (N-methyl)urea. The cytotoxic effects of the compounds were examined on three human malignant cell lines (HeLa, K562, and MCF7), and normal lung fibroblasts MRC-5.
View Article and Find Full Text PDFFront Chem
September 2024
Advanced Materials Division, Mintek, Randburg, South Africa.
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