AI Article Synopsis
- The study introduces stable analogs of the bacterial transferase MraY's substrate or product, incorporating a pyrophosphate surrogate.
- Researchers designed β-ketophosphonates to serve as bioisosteres for pyrophosphate and tested them as mimics of UDP-GlcNAc.
- The approach enables the addition of structural diversity later in the synthesis process, and the synthesized compounds were tested for their activity on the MraY enzyme.
Article Abstract
Stable analogs of bacterial transferase MraY substrate or product with a pyrophosphate surrogate in their structure are described. β-ketophosphonates were designed as pyrophosphate bioisosteres and were investigated as UDP-GlcNAc mimics. The developed strategy allows introduction of structural diversity at a late stage of the synthesis. The biological activity of the synthesized compounds was evaluated on the MraY enzyme.
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| http://dx.doi.org/10.1039/c1ob06124k | DOI Listing |
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