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A real-world Pharmacovigilance study of brodalumab based on the FDA adverse event reporting system.
Sci Rep
January 2025
Department of Dermatology, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, China.
Brodalumab, a humanized monoclonal antibody that targets the interleukin-17 receptor A, is primarily used to manage moderate-to-severe plaque psoriasis. Although it has demonstrated favorable efficacy and safety in clinical trials, the strict inclusion and exclusion criteria may not fully reflect its safety profile in real-world settings. As its use becomes more widespread in clinical practice, understanding its safety in real-world applications is crucial.
View Article and Find Full Text PDFNutrient distribution and nitrate processing in a mangrove tidal creek affected by submarine groundwater discharge (SGD).
Mar Pollut Bull
January 2025
State Key Laboratory of Marine Geology, Tongji University, Shanghai 200092, China.
Investigations of the spatial-temporal variations of nutrients within mangrove coastal zones are essential for assessing the environmental status of an aquatic ecosystems. However, major processes controlling nitrate cycle along the submarine groundwater discharge (SGD) pathway from the mangrove areas to adjacent tidal creek remain underexplored. A time series measurement over a 25 h tidal cycle was conducted in Qinglan Bay tidal creek (Hainan Island, China).
View Article and Find Full Text PDFDual controls of vapour pressure deficit and soil moisture on photosynthesis in a restored temperate bog.
Sci Total Environ
January 2025
Institute of Ecology and Earth Sciences, University of Tartu, Vanemuise Street. 46, 51003 Tartu, Estonia. Electronic address:
Despite only covering ~3 % of the land mass, peatlands store more carbon (C) per unit area than any other ecosystem. This is due to the discrepancy between C fixed by the plants (Gross primary productivity (GPP)) and decomposition. However, this C is vulnerable to frequent, severe droughts and changes in the peatland microclimate.
View Article and Find Full Text PDFRisk characterisation of chemicals of emerging concern in real-life water reuse applications.
Environ Int
January 2025
Institute for Biodiversity and Ecosystem Dynamics, University of Amsterdam, Amsterdam, The Netherlands.
Water reuse is a viable option to address temporal or structural water shortages. However, the ubiquitous presence of chemicals of emerging concern (CECs) in natural systems, especially the aquatic environment, represents a significant obstacle to water reuse and the receiving environment. Therefore, an extensive literature review was performed to identify current water reuse practices at field scale, reported types and levels of CECs and their associated risks for human and environmental health.
View Article and Find Full Text PDF[Evaluation of the psychometric properties of the 8-item Morisky medication adherence scale (MMAS-8) for oral anticoagulants in the Spanish population].
Semergen
January 2025
Departamento de Psicología de la Salud, Universidad Miguel Hernández, Elche, Alicante, España.
Aim: The use of oral anticoagulants has increased due to the rising prevalence of auricular fibrillation, a condition that raises the risk of thromboembolic events. These drugs are effective in preventing such events, but their success depends on therapeutic adherence, which requires validated tools for assessment. The aim of this study is to evaluate the suitability of the Morisky Medication Adherence Scale-8 (MMAS-8) questionnaire in its adapted version for the Spanish population.
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