Purpose: Adequate tissue oxygenation is essential for healing. Hyperbaric oxygen therapy (HBOT) has potential clinical applications to treat ischemic pathologies, however the exact nature of any protective effects are unclear at present. We therefore investigated the potential role of HBOT in modulating the ischemia/reperfusion (I/R) injury response in intestinal model of I/R injury.
Methods: Male Wistar rats were subjected to surgery for the induction of intestinal ischemia followed by reperfusion. HBOT was provided before and/or after intestinal ischemia. Cell viability in the intestinal tissue was assessed using the MTT assay and by measuring serum malondealdehyde (MDA). Microvascular density and apoptosis were evaluated by immunohistochemistry.
Results: The results indicate that HBOT treatment pre- and post-ischemia reduces lesion size to the intestinal tissue. This treatment increases cell viability and reduces the activation of caspase-3, which is associated with increased number of tissue CD34 cells and enhanced VEGF expression.
Conclusion: The hyperbaric oxygen therapy can limit tissue damage due to ischemia/reperfusion injury, by inducing reparative signaling pathways.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1590/s0102-86502011000600010 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Effects of adjuvant hyperbaric oxygen therapy and real-time fluorescent imaging on deep sternal wound infection: a retrospective study.
J Wound Care
January 2025
Division of Plastic Surgery, Integrated Burn & Wound Care Center, Department of Surgery, Shuang-Ho Hospital, New Taipei City, Taiwan.
Objective: Deep sternal wound infection (DSWI) is a rare but devastating complication that is estimated to occur in 1-2% of patients after median sternotomy. Current standard of care (SoC) comprises antibiotics, debridement and negative pressure wound therapy (NPWT). Hyperbaric oxygen therapy (HBOT) appears to be an effective adjuvant therapy for osteomyelitis.
View Article and Find Full Text PDFThe impact of workplace bullying on depression among clinical nurses in China: A comparative analysis.
Medicine (Baltimore)
January 2025
Department of ICU, Ningbo Medical Centre Lihuili Hospital, Ningbo University, Ningbo, Zhejiang, China.
The objective of this study is to examine the phenomenon of workplace bullying and its potential associations with burnout and depression among clinical nurses in China. A convenience sampling method was utilized to conduct a survey among 415 clinical nurses across 9 hospitals. All questionnaires were completed within a 2-week period in October 2023.
View Article and Find Full Text PDFGenerative Artificial Intelligence: Applications in Scientific Writing and Data Analysis in Wound Healing Research.
Adv Skin Wound Care
January 2025
At the Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, New York, United States, Adrian Chen, BS, Aleksandra Qilleri, BS, and Timothy Foster, BS, are Medical Students. Amit S. Rao, MD, is Project Manager, Department of Surgery, Wound Care Division, Northwell Wound Healing Center and Hyperbarics, Northwell Health, Hempstead. Sandeep Gopalakrishnan, PhD, MAPWCA, is Associate Professor and Director, Wound Healing and Tissue Repair Analytics Laboratory, School of Nursing, College of Health Professions, University of Wisconsin-Milwaukee. Jeffrey Niezgoda, MD, MAPWCA, is Founder and President Emeritus, AZH Wound Care and Hyperbaric Oxygen Therapy Center, Milwaukee, and President and Chief Medical Officer, WebCME, Greendale, Wisconsin. Alisha Oropallo, MD, is Professor of Surgery, Donald and Barbara Zucker School of Medicine and The Feinstein Institutes for Medical Research, Manhasset New York; Director, Comprehensive Wound Healing Center, Northwell Health; and Program Director, Wound and Burn Fellowship program, Northwell Health.
Generative artificial intelligence (AI) models are a new technological development with vast research use cases among medical subspecialties. These powerful large language models offer a wide range of possibilities in wound care, from personalized patient support to optimized treatment plans and improved scientific writing. They can also assist in efficiently navigating the literature and selecting and summarizing articles, enabling researchers to focus on impactful studies relevant to wound care management and enhancing response quality through prompt-learning iterations.
View Article and Find Full Text PDFUltrasound-Triggered Oxygen Release System for Accelerating Wound Healing of Diabetic Foot Ulcers.
Adv Healthc Mater
January 2025
Department of Pharmaceutics, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China.
Diabetic foot ulcer (DFU) is a common complication of chronic diabetes mellitus. Oxygen plays a critical role in the healing process of DFU wounds by promoting cell migration and neovascularization. However, clinical hyperbaric oxygen (HBO) therapy predominantly uses systemic oxygen administration, posing challenges in inadequate DFU local oxygen penetration and potential ectopic organs oxygen toxicity.
View Article and Find Full Text PDFA novel treatment strategy with hyperbaric oxygen of chronic osteomyelitis and pseudoarthrosis in a child with congenital hereditary sensory and autonomic neuropathy type 4 congenital insensitivity to pain with anhidrosis syndrome: a case report.
J Med Case Rep
January 2025
Department of Orthopaedics, Sahlgrenska University Hospital, Gothenburg, Sweden.
Background: Congenital insensitivity to pain with anhidrosis is a rare but devastating hereditary disease. Congenital insensitivity to pain with anhidrosis is caused by a mutation in the neurotrophic receptor tyrosine kinase 1 gene (NRTK1). The condition is characterized by multiple injuries, recurrent infections, and mental retardation.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!