We present an extension of the recently introduced Generalized Matrix Learning Vector Quantization algorithm. In the original scheme, adaptive square matrices of relevance factors parameterize a discriminative distance measure. We extend the scheme to matrices of limited rank corresponding to low-dimensional representations of the data. This allows to incorporate prior knowledge of the intrinsic dimension and to reduce the number of adaptive parameters efficiently. In particular, for very large dimensional data, the limitation of the rank can reduce computation time and memory requirements significantly. Furthermore, two- or three-dimensional representations constitute an efficient visualization method for labeled data sets. The identification of a suitable projection is not treated as a pre-processing step but as an integral part of the supervised training. Several real world data sets serve as an illustration and demonstrate the usefulness of the suggested method.
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http://dx.doi.org/10.1016/j.neunet.2011.10.001 | DOI Listing |
Catheter Cardiovasc Interv
January 2025
The Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Background: Limited data exist on the impact of polyvascular disease (PolyVD) on clinical outcomes in female patients undergoing transcatheter aortic valve replacement (TAVR). We therefore sought to investigate clinical outcomes in women with versus without PolyVD undergoing TAVR.
Methods: Female participants from the multicentre Women's International Transcatheter Aortic Valve Implantation (WIN-TAVI) registry were categorized based on the presence or absence of PolyVD.
PLoS One
January 2025
Mwanza Research Centre, National Institute for Medical Research, Mwanza, Tanzania.
The increased burden of non-communicable diseases (NCDs) is fueled by lifestyle factors including diet. This cross-sectional study explored among Tanzanian adults whether unhealthy dietary patterns are associated with intestinal and systemic inflammation which could increase the risk of NCDs. The study included 574 participants, with both diet and inflammatory markers data.
View Article and Find Full Text PDFInt J Mol Sci
December 2024
Medical Department III, Munich University Hospital, 81377 Munich, Germany.
There is a high medical need to develop new strategies for the treatment of patients with acute myeloid leukemia (AML) refractory to conventional therapy. In vitro, the combinations of the blast-modulatory response modifiers GM-CSF + Prostaglandin E1, (summarized as Kit M) have been shown to convert myeloid leukemic blasts into antigen-presenting dendritic cells of leukemic origin (DC) that were able to (re-)activate the innate and adaptive immune system, direct it specifically against leukemic blasts, and induce memory cells. This study aimed to investigate the immune modulatory capacity and antileukemic efficacy of Kit M in vivo.
View Article and Find Full Text PDFJ Clin Med
December 2024
Department of Maxillofacial Surgery, University of Siena, 53100 Siena, Italy.
: Currently, there is a lack of a comprehensive classification system for soft-palate defects that provides synthetic information to guide functional reconstructive treatment. Our awareness, shaped by extensive experience, of the superiority of myomucosal flaps to fasciocutaneous flaps in functional palate reconstruction has driven us to introduce a new defect-based classification system and propose a new algorithm for reconstructing soft-palate defects using buccinator myomucosal flaps. : Soft-palate defects were classified into five classes.
View Article and Find Full Text PDFCancers (Basel)
December 2024
Department of Biochemistry, Faculty of Science, Mahidol University, Bangkok 10400, Thailand.
Background: Cancer immune evasion is a multifaceted process that synchronizes pro-tumoral immune infiltration, immunosuppressive inflammation, and inhibitory immune checkpoint expression (IC). Current immunotherapies combat this issue by reinstating immunosurveillance of tumors; however, it benefits a limited patient population. Thus, a more effective immunotherapeutic strategy is warranted to cater to specific patient populations.
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