AI Article Synopsis
- A new method combining Mannich-type multicomponent assembly with 1,3-dipolar cycloaddition has been created to quickly and effectively build a specific chemical structure known as tetrahydroisoquinoline fused isoxazolidine.
- This newly formed structure can be further modified using established techniques to create a wide variety of chemical compounds.
- The result is a diverse library of 70 different novel derivatives that belong to a specific category of compounds known as hexahydro-1H-pyrido[2,1-a]isoquinoline-2-amines.
Article Abstract
A Mannich-type multicomponent assembly process/1,3-dipolar cycloaddition strategy has been developed for the rapid and efficient construction of a parent tetrahydroisoquinoline fused isoxazolidine scaffold, which was subsequently functionalized using well-established protocols to access a diverse 70-membered library of novel 2,3,4,6,7,11b-hexahydro-1H-pyrido[2,1-a]isoquinoline-2-amine derivatives.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3253940 | PMC |
| http://dx.doi.org/10.1021/co2001636 | DOI Listing |
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