AI Article Synopsis
- A new method is introduced for creating fluorescent cyclotriveratrylene (CTV) probes, focusing on a key intermediate called triiodo CTV.
- The synthesis of triiodo CTV is achieved in three steps with a 47% yield and requires just one purification step.
- This intermediate is used to develop a fluorescent probe that selectively binds to choline over acetylcholine, enabling the rapid creation of a library of probes for further research.
Article Abstract
A new strategy to obtain fluorescent cyclotriveratrylene (CTV) probes is proposed. The key intermediate, a triiodo CTV, is prepared in 3 steps with 47% overall yield. The whole synthesis requires only one purification step. The potential of this triiodo CTV as an intermediate is illustrated through the synthesis of a fluorescent phosphorylated probe that is able to bind choline and acetylcholine in pseudo-physiological conditions, with selectivity towards choline. As a consequence, this intermediate should allow us to rapidly form a library of probes in order to highlight the most promising ones.
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| http://dx.doi.org/10.1039/c1ob06231j | DOI Listing |
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