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Aberrant E-cadherin Expression in Lobular Carcinoma In Situ: A Comprehensive Immunohistochemical Evaluation of N-terminal, Extracellular, and C-terminal E-cadherin Domains.
Am J Surg Pathol
January 2025
Instituto de Anatomia Patológica, Faculdade de Medicina da Universidade de Lisboa.
E-cadherin (E-cad) immunohistochemistry is commonly used to distinguish lobular carcinoma in situ (LCIS) from ductal carcinoma in situ in histologically uncertain or ambiguous cases. Although most LCIS cases show an absence of E-cad expression on the neoplastic cell membranes, some show aberrant E-cad expression which can lead to diagnostic confusion. Awareness and understanding of the frequency, patterns, and distribution of aberrant E-cad staining in LCIS is crucial to achieving a correct diagnosis.
View Article and Find Full Text PDFSurgery for Classic, Pleomorphic and Non-classic Lobular Carcinoma In Situ: Surgery Rate, Risk of Upstaging and Short-Term Follow-Up.
Ann Surg Oncol
December 2024
Laboratory of Pathology Dordrecht, Dordrecht, The Netherlands.
Background: The Dutch breast cancer guideline recommends surveillance for classic lobular carcinoma in situ (LCIS), unless there is a discrepancy with mammographic findings, and surgery for pleomorphic and non-classic LCIS.
Objective: The aim of this study was to assess adherence to the guideline in daily practice, as well as the surgery rate, risk of upstaging, and events during follow-up.
Methods: Selection of patients from a nationwide cohort diagnosed between 2011 and 2020.
Small intestinal metastasis from primary breast cancer: a case report and review of literature.
Front Immunol
December 2024
Department of Breast and Thyroid Surgery, Shaoxing People's Hospital, Shaoxing, China.
Small intestinal metastasis from primary breast cancer remains a rare clinical occurrence. Despite extensive research into its clinicopathological features and treatment options, the specific pathogenesis and optimal management strategies remain incompletely understood. This case report presents a patient with breast cancer that metastasized to the small intestine.
View Article and Find Full Text PDFNuclear morphological characterisation of lobular carcinoma variants: a morphometric study.
Histopathology
December 2024
Academic Unit for Translational Medical Sciences, School of Medicine, University of Nottingham, Nottingham, UK.
Background And Aims: Lobular carcinoma (LC) of the breast exhibits diverse morphology and clinical behaviour. The pleomorphic variant (pLC) displays distinct cytonuclear features and aggressiveness compared to the classic variant (cLC). However, diagnosing pLC remains subjective.
View Article and Find Full Text PDFExpression of PD-L1 in breast invasive lobular carcinoma.
PLoS One
October 2024
Department of Pathology, Yonsei University College of Medicine, Seoul, South Korea.
Article Synopsis
- - The study aimed to explore PD-L1 expression in invasive lobular carcinoma (ILC) and its potential implications for cancer treatment.
- - Researchers created tissue arrays from 101 ILC cases and used immunohistochemical staining to analyze PD-L1 levels, finding that tumor cell positivity was low (0-2%) and immune cell positivity varied significantly (0-21.8%).
- - Higher PD-L1 expression in immune cells was linked to factors like nuclear grade and HER-2 positivity, suggesting that certain types of ILC, particularly the pleomorphic type, may have more significant PD-L1 involvement.
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