AI Article Synopsis
- In Mexico, over 45 million doses of influenza vaccines were administered from December 2009 to June 2010, with a focus on assessing any adverse events linked to these vaccinations.
- A total of 597 cases of events temporarily associated with vaccination (ETAV) were recorded, predominantly affecting individuals aged 20 to 49 years, with a higher notification rate for the H1N1 vaccine compared to the seasonal vaccine.
- The study found no increased incidence of Guillain-Barré Syndrome beyond expected levels in the general population, suggesting that serious adverse events were coincidental and unrelated to the vaccines.
Article Abstract
Background And Aims: In Mexico from December 2009 to June 2010, 45,490,501 doses of the vaccine against the influenza virus were administered; 27,048,330 of those corresponded to influenza A (H1N1) and 18,442,171 to seasonal influenza. Therefore, the assessment of events temporarily associated with vaccination (ETAV) is mandatory.
Methods: The database corresponding to the ETAV associated with influenza (A [H1N1] and seasonal) immunization reported between December 2009 and June 2010 was analyzed. Patients who displayed at least one ETAV with one of the following schedules were included: A) influenza A (H1N1) vaccine, B) seasonal influenza vaccine, C) influenza A (H1N1) vaccine and seasonal influenza vaccine.
Results: A total of 597 ETAVs were reported. The 20- to 49-year-old age group was the most affected one (52.9%). The ETAV notification rate for influenza A (H1N1) vaccination was 1.41/100,000 applied doses vs. 0.74/100,000 applied doses corresponding to the seasonal influenza vaccination. Fifty seven events were considered serious (14 corresponded to Guillain-Barré syndrome) and these were considered coincidental unrelated events.
Conclusions: There is no evidence of an increased rate of Guillain-Barré Syndrome with respect to the cases expected in the general population.
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| http://dx.doi.org/10.1016/j.arcmed.2011.10.007 | DOI Listing |
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