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A case of polyarteritis nodosa with severe lower limb ulcer that was treated with prednisolone and tocilizumab.
Mod Rheumatol Case Rep
December 2024
Nephrology Center and Okinaka Memorial Institute for Medical Research, Toranomon Hospital Kajigaya, Kanagawa, Japan.
Polyarteritis nodosa (PAN) is a rare systemic necrotizing vasculitis that can lead to the formation of refractory lower limb ulcers requiring amputation. The standard treatment for severe PAN involves combination therapy with steroids and cyclophosphamide; however, some cases prove to be challenging. Recently, case reports have described the use of biological agents for PAN treatment.
View Article and Find Full Text PDFMisdiagnosed for 14 Years: Adenosine Deaminase 2 (ADA2) Deficiency in a Teen Mimicking Polyarteritis Nodosa.
Clin Case Rep
November 2024
Department of Rheumatology, Autoimmune Disease Research Center, Beheshti Hospital Kashan University of Medical Sciences Kashan Iran.
The deficiency of adenosine deaminase 2 (DADA2) is an autosomal recessive disorder caused by loss of function mutations in the ADA2 gene (previously the CECR1 gene) on chromosome 22q11. The clinical spectrum of the disease is remarkably broad, and its presentations mimic features of polyarteritis nodosa, such as livedoid rash, hematological abnormalities (e.g.
View Article and Find Full Text PDFSuccessful treatment of cutaneous polyarteritis nodosa with baricitinib.
J Dermatolog Treat
December 2024
Dermatology Center, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Polyarteritis nodosa (PAN) is a rare systemic necrotizing vasculitis preferentially targeting medium-sized arteries. PAN has two clinical entities: systemic PAN (sPAN) and cutaneous PAN (cPAN). cPAN is a skin-limited vasculitis, while ulcerative cPAN often predicts a higher risk of recurrence and a worse prognosis.
View Article and Find Full Text PDFThe coincidence of multiple sclerosis and primary vasculitis; from the bench of pathology to the bedside of treatment: a systematic review of case reports.
Neurol Sci
January 2025
Multiple Sclerosis Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran.
Article Synopsis
- Multiple sclerosis (MS) is a chronic disease that severely affects quality of life and can co-occur with various other conditions, including primary vasculitis, which complicates diagnosis and treatment.
- A systematic review was conducted analyzing research from 1974 to 2023, focusing on the relationship between MS and different types of primary vasculitis, ultimately including 18 studies with data on 18 patients across 14 countries.
- The findings indicate that many patients experienced MS before developing vasculitis, highlighting the importance of considering vasculitis as a significant comorbidity in MS patients, especially when atypical symptoms arise.
Case report: Cutaneous polyarteritis nodosa presenting with ulcers in atypical localizations and atypical skin rashes: A report of a rare case.
Int J Rheum Dis
August 2024
Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, Erciyes University, Kayseri, Turkey.
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