In this paper we present efficient algorithms for sorting on the Parallel Disks Model (PDM). Numerous asymptotically optimal algorithms have been proposed in the literature. However many of these merge based algorithms have large underlying constants in the time bounds, because they suffer from the lack of read parallelism on PDM. The irregular consumption of the runs during the merge affects the read parallelism and contributes to the increased sorting time. In this paper we first introduce a novel idea called the dirty sequence accumulation that improves the read parallelism. Secondly, we show analytically that this idea can reduce the number of parallel I/O's required to sort the input close to the lower bound of [Formula: see text]. We experimentally verify our dirty sequence idea with the standard R-Way merge and show that our idea can reduce the number of parallel I/Os to sort on PDM significantly.
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http://dx.doi.org/10.1016/j.jpdc.2011.07.004 | DOI Listing |
Plant Cell Physiol
January 2025
Laboratory for Chemistry and Life Science, Institute of Innovative Research, Institute of Science Tokyo, Yokohama, Japan.
The unicellular red alga Cyanidioschyzon merolae is a eukaryotic photosynthetic model organism used for basic and applied cell biology studies. Its nuclear genome can be modified by homologous recombination with exogenously introduced DNA. The comparison of mutants with isogenic strains is critical for reliable genetic analyses; however, this has been impossible thus far.
View Article and Find Full Text PDFEnviron Health Insights
January 2025
Department of Theology and Religious Education, College of Liberal Arts, De La Salle University, Manila, Philippines.
I read with great interest the recent study by Omohwovo on wastewater management challenges in Africa, which has strong parallels with the Philippines' own struggles in this area. Like Africa, our country is experiencing rapid population growth and urbanization without the necessary infrastructure to support effective wastewater treatment. The Philippines is also facing poor wastewater management that has led to severe heath concerns for humans, animals, and ecosystem.
View Article and Find Full Text PDFJ Glob Antimicrob Resist
January 2025
Institut National de la Santé et de la Recherche Médicale (UMR 1071), Institut National de la Recherche Agronomique (USC-2018), Université Clermont Auvergne, Clermont-Ferrand, France; Centre National de Référence de la Résistance aux Antibiotiques, Centre Hospitalier Universitaire, Clermont-Ferrand, France.
Background: Colistin is a last-line antibiotic used to treat severe human infections caused by carbapenemase-producing Gram-negative bacteria. In parallel, colistin has massively been used in the veterinary field so that mcr-1-positive E. coli have spread worldwide in livestock, potentially constituting a reservoir of colistin-resistant isolates that can be further transmitted to humans.
View Article and Find Full Text PDFClin Chem
January 2025
Division of Genomic and Molecular Pathology, Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, United States.
Background: Massively parallel sequencing (MPS) of nucleic acids has been a transformative technology for basic and applied genomic science, increasing efficiencies and decreasing costs to enable studies of unprecedented scope and impact. In clinical settings, these technological and scientific advances have led to the development of tests that are increasingly fast, comprehensive, and more frequently employed. Practitioners of genomic medicine have applied these tools across clinical settings, including diagnosis of inherited disorders and cancers and infectious disease detection and surveillance.
View Article and Find Full Text PDFJ Crohns Colitis
January 2025
Amsterdam UMC, Department of Gastroenterology and Hepatology, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands.
Introduction: It remains unclear why up to 30% of ulcerative colitis patients (UC) do not respond to tumor necrosis factor inhibitors (TNFi). Validated biomarkers for (non-)response ((N)R) are lacking. Most studies investigating underlying mechanisms do not differentiate between pharmacokinetic and inflammatory mechanisms.
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