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Presents an obituary for Stanley Moldawsky, who passed away on February 9, 2018. Moldawsky was a retired clinical psychologist and an adjunct visiting professor at the Graduate School of Applied and Professional Psychology (GSAPP) at Rutgers, the State University of New Jersey. With several close colleagues, he was not only instrumental in establishing the GSAPP but was also tenacious in working to obtain state approval and an academic home for their collaborative aspiration.
View Article and Find Full Text PDFDivergent lactate dehydrogenase isoenzyme profile in cellular compartments of primate forebrain structures.
Mol Cell Neurosci
July 2017
Department of Anthropology and Center for the Advanced Study of Human Paleobiology, The George Washington University, Washington, DC 20052, USA. Electronic address:
The compartmentalization and association of lactate dehydrogenase (LDH) with specific cellular structures (e.g., synaptosomal, sarcoplasmic or mitochondrial) may play an important role in brain energy metabolism.
View Article and Find Full Text PDFHigh-throughput RNA sequencing reveals structural differences of orthologous brain-expressed genes between western lowland gorillas and humans.
J Comp Neurol
February 2016
Center for Molecular Medicine and Genetics, Wayne State University, Detroit, Michigan, 48201.
Article Synopsis
- The research highlights significant differences in gene structure and transcription between humans and the western lowland gorilla, despite their close evolutionary relationship.
- A study of the gorilla's brain transcriptome revealed unique genes that are absent in humans, especially in regions related to immunity and energy metabolism, accounting for 134 missing amino acids in proteins.
- This work provides a valuable resource for understanding the genetic basis of cognitive differences between humans and other great apes by cataloging unique sequences and structures in the gorilla brain.
Synaptosomal lactate dehydrogenase isoenzyme composition is shifted toward aerobic forms in primate brain evolution.
Brain Behav Evol
January 2015
Department of Anthropology, The George Washington University, Washington, D.C., USA.
With the evolution of a relatively large brain size in haplorhine primates (i.e. tarsiers, monkeys, apes, and humans), there have been associated changes in the molecular machinery that delivers energy to the neocortex.
View Article and Find Full Text PDFCharacterization of human cortical gene expression in relation to glucose utilization.
Am J Hum Biol
November 2013
Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, MI 48201, USA.
Article Synopsis
- - The study aims to explore how gene expression in the human brain changes as a person ages, focusing on brain development from infancy to adulthood and its connection to glucose utilization patterns.
- - Researchers used microarrays to analyze mRNA expression in human brain tissue, discovering 40 genes with notable age-related expression changes, including some linked to nervous system development.
- - They found evidence of adaptive evolution in gene regulation, suggesting that certain genes may influence brain development and highlight a potential link to glucose consumption in the brain.
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