Objectives: Walking or cycling to school represents an opportunity for children to engage in physical activity. The study objectives were to: 1) describe active transportation policies, programs, and built environments of Canadian schools and their surrounding neighbourhoods, and 2) document variations based on urban-rural location and school type (primary vs. secondary vs. mixed primary/secondary schools).
Methods: 397 schools from across Canada were studied. A school administrator completed a questionnaire and responses were used to assess schools' policies and programs related to active transportation and the safety and aesthetics of their respective neighbourhoods. Built environment features in a 1 km-radius circular buffer around each school were measured using geographic information systems.
Results: Greater than 70% of schools had passive policies (e.g., skateboards permitted on school grounds) and facilities (e.g., bicycle racks in secure area to avoid theft) to encourage bicycle and small-wheeled vehicle use. Less than 40% of schools had active programs designed to encourage active transportation, such as organized 'walk to school' days. Garbage in the streets, crime and substance abuse were barriers in most school neighbourhoods. Approximately 42% of schools were located on high-speed roads not amenable to active transportation and 14% did not have a sidewalk leading to the school. Secondary schools had less favourable active transportation policies/programs and neighbourhood safety/aesthetics compared to primary schools. Rural schools had less favourable built environments than urban schools.
Conclusion: Canadian children, particularly those from rural areas, face a number of impediments to active transportation as a method of travelling to school.
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http://dx.doi.org/10.1007/BF03404178 | DOI Listing |
Sci Rep
December 2024
Henan College of Transportation, Zhengzhou, 450000, Henan, China.
Novel Human Activity Recognition (HAR) methodologies, which are built upon learning algorithms and employ ubiquitous sensors, have achieved remarkable precision in the identification of sports activities. Such progress benefits all age groups of humanity, and in the future, AI will be used to address difficult problems in scientific research. A novel approach is introduced in this article to utilize motion sensor data in order to categorize and distinguish various categories of sports activities.
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December 2024
Department of Mechanical Engineering, Carnegie Mellon University, Pittsburgh, PA, USA.
Polymer electrolyte membrane water electrolyzers (PEMWEs) are a critical technology for efficient hydrogen production to decarbonize fuels and industrial feedstocks. To make hydrogen cost-effective, the overpotentials across the cell need to be decreased and platinum-group metal loading reduced. One overpotential that needs to be better understood is due to mass transport limitations from bubble formation within the porous transport layer (PTL) and anode catalyst layer (ACL), which can lead to a reduction in performance at typical operating current densities.
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December 2024
Nanobiology Institute, Yale University, West Haven, CT, USA.
Neurotransmitters are released from synaptic vesicles with remarkable precision in response to presynaptic calcium influx but exhibit significant heterogeneity in exocytosis timing and efficacy based on the recent history of activity. This heterogeneity is critical for information transfer in the brain, yet its molecular basis remains poorly understood. Here, we employ a biochemically-defined fusion assay under physiologically relevant conditions to delineate the minimal protein machinery sufficient to account for various modes of calcium-triggered vesicle fusion dynamics.
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December 2024
Department of Synthetic Biology and Immunology, National Institute of Chemistry, Ljubljana, Slovenia.
Inflammasomes are defense complexes that utilize cytokines and immunogenic cell death (ICD) to stimulate the immune system against pathogens. Inspired by their dual action, we present cytokine-armed pyroptosis as a strategy for boosting immune response against diverse types of tumors. To induce pyroptosis, we utilize designed tightly regulated gasdermin D variants comprising different pore-forming capabilities and diverse modes of activation, representing a toolbox of ICD inducers.
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December 2024
Department of Ophthalmology, Columbia University, New York, NY, USA.
Best1 and Best2 are two members of the bestrophin family of anion channels critically involved in the prevention of retinal degeneration and maintenance of intraocular pressure, respectively. Here, we solved glutamate- and γ-aminobutyric acid (GABA)-bound Best2 structures, which delineate an intracellular glutamate binding site and an extracellular GABA binding site on Best2, respectively, identified extracellular GABA as a permeable activator of Best2, and elucidated the co-regulation of Best2 by glutamate, GABA and glutamine synthetase in vivo. We further identified multiple small molecules as activators of the bestrophin channels.
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