The aim of this study was to analyze the limits and possibilities of the Information System in the Schistosomiasis Control Program (SISPCE) for characterization and surveillance of the disease at the local level. The data were aggregated to calculate epidemiological indicators such as the program's coverage and intensity of mansoni schistosomiasis infection in the endemic municipalities (counties) in Bahia State, Brazil, from 1999 to 2005. The results indicate that few municipalities have the program activities properly in place, with insufficient records in the system and lack of reporting for characterizing the endemic or providing feedback for proper surveillance and control. However, the SISPCE is still a step forward in schistosomiasis surveillance, requiring systematic action by the municipalities and maintaining a continuous data flow to orient health system managers. It is necessary to incorporate local communities as units of analysis, given their unique characteristics in the production and reproduction of schistosomiasis.
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http://dx.doi.org/10.1590/s0102-311x2011001000018 | DOI Listing |
Health Sci Rep
January 2025
Gerhard-Domagk Institute of Pathology University Hospital Muenster (UKM) Muenster Germany.
Background And Aims: Benign lesions, inflammation, cysts and pseudocysts, as well as neoplasms of the exocrine and endocrine parts of the pancreas can be easily identified using cytological methods. The sensitivity and specificity can be increased with the help of additional examination methods. The sensitivity of intraoperative rapid cytology reaches about 99%.
View Article and Find Full Text PDFHum Reprod Open
January 2025
Regional Center of Pharmacovigilance, Pharmacology Department, Cochin Hospital, AP-HP.Centre-Université Paris Cité, Paris, France.
Study Question: Is there an association between dydrogesterone exposure during early pregnancy and the reporting of birth defects?
Summary Answer: This observational analysis based on global safety data showed an increased reporting of birth defects, mainly hypospadias and congenital heart defects (CHD), in pregnancies exposed to dydrogesterone, especially when comparing to progesterone.
What Is Known Already: Intravaginal administration of progesterone is the standard of care to overcome luteal phase progesterone deficiency induced by ovarian stimulation in ART. In recent years, randomized controlled clinical trials demonstrated that oral dydrogesterone was non-inferior for pregnancy rate at 12 weeks of gestation and could be an alternative to micronized vaginal progesterone.
Math Biosci Eng
December 2024
Department of Engineering and Natural Sciences, University of Applied Sciences Merseburg, Eberhard-Leibnitz-Str. 2, D-06217 Merseburg, Germany.
In this article, we reconsider the classical target cell limited dynamical within-host HIV model, solely taking into account the interaction between $ {\rm{CD}}4^{+} $ T cells and virus particles. First, we summarize some analytical results regarding the corresponding dynamical system. For that purpose, we proved some analytical results regarding the system of differential equations as our first main contribution.
View Article and Find Full Text PDFJ Med Chem
January 2025
Université de Caen Normandie, CERMN UR4258, Normandie Univ, F-14000 Caen, France.
UBE2N protein belongs to the UE2s family and plays a crucial role in DNA repair, making it an exciting target for the development of innovative anticancer therapies. With the aim of discovering UBE2N inhibitors (UBE2Ni), this perspective seeks to review and provide elements to guide the design of new compounds. We propose a chemoinformatic structural analysis of the protein and its areas of interaction with its different partners.
View Article and Find Full Text PDFSci Rep
January 2025
Chengdu Engineering Corporation Limited, Chengdu, 610072, China.
The proportion of railway high-altitude buried tunnels in complex and dangerous mountainous areas in southwest China is exceptionally high. With the characteristics of suddenness, intermittency, instantaneousness, and destruction, inrushinrushing and collapse is one of the main risks in the tunnel construction process. Therefore, in the design and construction process of tunnels in Hengduan Mountain area, it is very important to identify the mechanism of sudden s inrushing and collapse risks, predict the spatial location and scale of possible inrushing and collapse, and formulate corresponding tunnel design and construction response measures.
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