A novel synthesis of triazolo[1,2-a]indazole-1,3,8-trione derivatives by reaction of urazole, dimedone and aromatic aldehydes under conventional heating and microwave irradiation and solvent-free conditions using silica nanoparticles prepared from rice husk ash as catalyst is described. The new method features high yields, multicomponent reactions and environmental friendliness.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6264693PMC
http://dx.doi.org/10.3390/molecules16119041DOI Listing

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