Objective: Analyzing a group of females suffering from cancers concept of the quality of life and evaluating how they perceived such concept, depending on patients age-group.
Methods: The following open-ended question was put to a sample of 114 women suffering from breast cancer, "In your opinion, what is quality of life?" Their replies were analyzed using factorial methods for categorical variables.
Results: The most used graphical forms and repeated segments were associated with notions linked to well-being and health; analyzing characteristic forms supported these concepts importance. Some concepts appeared to be more relevant according to patient age-group. The young female group emphasized the right and opportunity to have adequate treatment whilst overcoming disease and response to its treatment were relevant to the 41-50 year-old group. Functioning and enjoyment were significant for the 51-60 year-old group whilst patients aged over 60 emphasized spiritual well-being. Binary correspondence analysis identified three domains: health (not just being the absence of disease or infirmity), autonomy or adequate dependence, and family/social well-being. Age-groups had differential representation regarding each domain.
Conclusions: Besides traditional domains, spirituality and a particular system guaranteeing access to quality health-care emerged as being important domains in female cancer patients perception of the quality of life. Quality of life is a multidimensional and dynamic concept that changes according to age; this suggested that quality of life is supported by subjective conceptualization; the use of scales for measuring quality of life could thus be questionable because of their subjectivity and dynamic nature.
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http://dx.doi.org/10.1590/s0124-00642010000600002 | DOI Listing |
Sci Rep
December 2024
Department of Neurobiology and Behavior, University of California Irvine, Irvine, CA, 92697, USA.
Preserving the ability to vividly recall emotionally rich experiences contributes to quality of life in older adulthood. While prior works suggest that moderate-intensity physical activity (MPA) may bolster memory, it is unclear whether this extends to emotionally salient memories consolidated during sleep. In the current study, older adults (mean age = 72.
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December 2024
Nehme and Therese Tohme Multiple Sclerosis Center, American University of Beirut Medical Center, Riad El-Solh, PO Box 11-0236, 1107 2020, Beirut, Lebanon.
Fatigue is one of the most prevalent and disabling symptoms among patients with MS, but there is limited research investigating the longitudinal determinants of fatigue progression. This study aims to identify the sociodemographic, behavioral and clinical characteristics, and therapeutic regimens that are correlated with worsening fatigue over time in patients diagnosed with MS. This is a retrospective chart review of 483 patients.
View Article and Find Full Text PDFNat Commun
December 2024
State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau, China.
Lipid nanoparticles (LNPs) have proven effective in mRNA delivery, as evidenced by COVID-19 vaccines. Its key ingredient, ionizable lipids, is traditionally optimized by inefficient and costly experimental screening. This study leverages artificial intelligence (AI) and virtual screening to facilitate the rational design of ionizable lipids by predicting two key properties of LNPs, apparent pKa and mRNA delivery efficiency.
View Article and Find Full Text PDFsurgery for rectal cancer often presents multiple tactical and technical challenges due to factors such as the tumor's extent, limited anatomical space, proximity to the anal sphincter complex, and the use of neoadjuvant radiotherapy. These factors can significantly increase the complexity of surgery and the risk of both immediate and delayed complications, which can occur intraoperatively or postoperatively. Objective: the aim of this study was to retrospectively analyze the causes, diagnostic methods, and management of complications in patients who underwent surgery for rectal cancer.
View Article and Find Full Text PDFcolorectal cancer is a common and serious condition, with surgical resection being the primary treatment for localized cases. Anastomotic dehiscence (AD) remains a significant postoperative complication, and anastomoses are typically created using either manual suturing or mechanical stapling, each with specific benefits and challenge. Material and this retrospective study analyzed outcomes in 100 rectal cancer patients who underwent surgical resection, with anastomoses performed via manual suturing (n=50) or mechanical stapling (n=50).
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