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ECM-mimicking hydrogel models of human adipose tissue identify deregulated lipid metabolism in the prostate cancer-adipocyte crosstalk under antiandrogen therapy.
Mater Today Bio
February 2025
School of Biomedical Sciences, Faculty of Health, and Translational Research Institute (TRI), Queensland University of Technology (QUT), Brisbane, QLD, 4102, Australia.
Antiandrogen therapies are effectively used to treat advanced prostate cancer, but eventually cancer adaptation drives unresolved metastatic castration-resistant prostate cancer (mCRPC). Adipose tissue influences metabolic reprogramming in cancer and was proposed as a contributor to therapy resistance. Using extracellular matrix (ECM)-mimicking hydrogel coculture models of human adipocytes and prostate cancer cells, we show that adipocytes from subcutaneous or bone marrow fat have dissimilar responses under the antiandrogen Enzalutamide.
View Article and Find Full Text PDFMachine learning and metagenomics identifies uncharacterized taxa inferred to drive biogeochemical cycles in a subtropical hypereutrophic estuary.
ISME Commun
January 2024
School of Chemistry and Molecular Biosciences, Australian Centre for Ecogenomics, The University of Queensland, QLD 4072, Australia.
Anthropogenic influences have drastically increased nutrient concentrations in many estuaries globally, and microbial communities have adapted to the resulting hypereutrophic ecosystems. However, our knowledge of the dominant microbial taxa and their potential functions in these ecosystems has remained sparse. Here, we study prokaryotic community dynamics in a temporal-spatial dataset, from a subtropical hypereutrophic estuary.
View Article and Find Full Text PDFSpatial, environmental and trophic niche partitioning by seabirds in a climate change hotspot.
J Anim Ecol
January 2025
Environmental Defense Fund, Seattle, Washington, USA.
For similar species to co-occur in places where resources are limited, they need to adopt strategies that partition resources to reduce competition. Our understanding of the mechanisms behind resource partitioning among sympatric marine predators is evolving, but we lack a clear understanding of how environmental change is impacting these dynamics. We investigated spatial and trophic resource partitioning among three sympatric seabirds with contrasting biological characteristics: greater crested terns Thalasseus bergii (efficient flyer, limited diver, and preference for high quality forage fish), little penguins Eudyptula minor (flightless, efficient diver, and preference for high quality forage fish) and silver gulls Chroicocephalus novaehollandiae (efficient flyer, limited diver and generalist diet).
View Article and Find Full Text PDFThe Effect of Assisted Reproductive Technologies on Human Sex Ratios.
Aust N Z J Obstet Gynaecol
January 2025
Reproductive Services Unit, The Royal Women's Hospital, Parkville, Australia.
Background: Modern assisted reproductive technology (ART), including pre-implantation genetic testing for aneuploidy (PGT-A), has opened new avenues in understanding early embryonic events and has simultaneously raised questions about the impact of ART itself on sex ratios.
Aims: The primary aim was to investigate whether patient demographic characteristics, ovarian stimulation protocols or laboratory characteristics in ART influence sex ratios. The secondary aim was to relate the blastocyst sex ratio (BSR) to the corresponding secondary sex ratio (SSR) in our patient cohort.
Preoperative Cardiac Assessment for Coronary Artery Disease: From Symptoms to Angiography.
J Cardiothorac Vasc Anesth
January 2025
Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Boston, MA.
Although cardiovascular anesthesiologists play a role in the multidisciplinary heart team, they are generally not involved prior to the diagnosis of coronary artery disease. This work was designed to broadly cover the factors influencing decision-making when proceeding with coronary angiography in a patient with suspected coronary artery disease. The authors cover the principles, rationale, benefits, and downsides of common tests involved.
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