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International consensus on research priorities in hypospadias using a Delphi study approach.
J Pediatr Urol
December 2024
Department of Public Health, College of Health Sciences, QU Health, Qatar University, P.O. Box 2713, Doha, Qatar.
Introduction: Hypospadias is a common congenital anomaly of the male genitalia that poses significant management and treatment challenges. Gaining a comprehensive understanding of priority research questions in hypospadiology will be essential to reach agreement on the optimal approach to assessment, treatment, and outcome prediction for affected patients.
Methods: We employed a consensus-building Delphi method to identify and prioritize research questions in the hypospadias field.
Structural Dynamics of Rho GTPases.
J Mol Biol
December 2024
Division of Experimental Hematology and Cancer Biology, Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA; University of Cincinnati College of Medicine, Cincinnati, OH, USA. Electronic address:
Rho family GTPases are a part of the Ras superfamily and are signaling hubs for many cellular processes. While the detailed understanding of Ras structure and function has led to tremendous progress in oncogenic Ras-targeted drug discovery, studies of the related Rho GTPases are still catching up as the recurrent cancer-related Rho GTPase mutations have only been discovered in the last decade. Like that of Ras, an in-depth understanding of the structural basis of how Rho GTPases and their mutants behave as key oncogenic drivers benefits the development of clinically effective therapies.
View Article and Find Full Text PDFReflect, Revise, Respond and Remember: Recollections of Lessons from My Mentors Based on 17th Dr. K. C. Chaudhuri and Dr. Amala Chaudhuri Oration, on 6th October 2024.
Indian J Pediatr
December 2024
Professor Emeritus Pediatrics, Sri Venkateshwaraa Medical College Hospital and Research Centre, Ariyur, Pondicherry, India.
The 48 y as a pediatrician, serving children and families was beyond attending to their presenting complaints. The combined roles as a child health doctor, medical teacher, researcher and administrator were interesting, nevertheless a tightrope walk. The lessons and wisdom that emerged from my learning journey, guided by my esteemed mentors, made me realise that the history and physical examination remain as the foundation of clinical assessment of a well or an ill child, even when we rely on technology to make a diagnosis.
View Article and Find Full Text PDFAssociation between dental agenesis and facial morphology. A cross-sectional study in France.
PLoS One
December 2024
CHU Rennes, Pôle Odontologie, Univ Rennes, Rennes, France.
Purpose: Knowing the features of dental evolution and facial morphology, marked by an increase in the prevalence of agenesis and a tendency towards verticalization of the face, the main objective of this cross-sectional observational study was to assess the correlation between the occurrence of agenesis (of 3rd molars or other teeth) and facial morphology in the French population.
Methods: The study was conducted at the University Hospital of Rennes, France, from June 2022 to October 2022. Patients aged 12-18 years who underwent a global orthodontic assessment were included.
Xuesanqi ameliorates DSS-induced colitis in mice by mediating gut microbiota dysbiosis and modulating MAPK/ERK/JNK pathway.
Nat Prod Bioprospect
December 2024
Wisdom Lake Academy of Pharmacy, Xi'an Jiaotong-Liverpool University, Suzhou, 215123, Jiangsu, People's Republic of China.
This study aimed to evaluate the therapeutic properties of the traditional Chinese medicine Xuesanqi (XSQ, from the rhizome of Polygonum amplexicaule D. Don) in treating ulcerative colitis. We hypothesized that its many active components can alleviate symptoms of colitis by regulating the gut microbiota, its metabolites, and various signaling pathways.
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