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The Cholesterol Paradox in Long-Livers from a Sardinia Longevity Hot Spot (Blue Zone).
Nutrients
February 2025
Dipartimento di Medicina, Chirurgia e Farmacia, University of Sassari, Clinica Medica, Viale San Pietro 8, 07100 Sassari, Italy.
: Hypercholesterolemia is commonly viewed as a risk factor for coronary heart disease; however, several studies have reported an inverse relationship between cholesterol levels and cardiovascular mortality, particularly in older adults. This "cholesterol paradox" challenges the conventional understanding of lipid metabolism. Despite often being dismissed as a result of reverse causality, the precise causes of this paradox remain poorly understood.
View Article and Find Full Text PDFRevisiting the "cholesterol paradox" in heart failure. Is LDL-cholesterol a target of treatment or a marker of risk?
Rev Port Cardiol
March 2025
Cardiology Department, Hospital Santa Cruz, Unidade Local de Saúde de Lisboa Ocidental, Lisbon, Portugal. Electronic address:
Association between blood lipids and diabetes mellitus in older Chinese adults aged 65 years or older: a cross-sectional analysis of residents' electronic health records.
Lipids Health Dis
June 2024
Zhejiang Provincial Center for Disease Control and Prevention, Dept. of Public Health Surveillance & Advisory, No.3399. Binsheng Road, Binjiang district, Hangzhou, 310051, PR China.
Aim: This study aimed to investigate how blood lipids are associated with diabetes among older Chinese adults.
Methods: 3,268,928 older Chinese adults without known diabetes were included. Logistic regression and restricted cubic spline (RCS) models were conducted to study associations between blood lipids (total cholesterol [TC], triglycerides [TG], low-density lipoprotein cholesterol [LDL-C], and high-density lipoprotein cholesterol [HDL-C]) and diabetes.
Cholesterol paradox in the community-living old adults: is higher better?
J Geriatr Cardiol
December 2023
Department of anti-NBC Medicine, Chinese PLA Medical School, Chinese PLA General Hospital, Beijing, China.
Objective: To evaluate the associations of lipid indicators and mortality in Beijing Elderly Comprehensive Health Cohort Study.
Methods: A prospective cohort was conducted based on Beijing Elderly Comprehensive Health Cohort Study with 4499 community older adults. After the baseline survey, the last follow-up was March 31, 2021 with an average 8.
Article Synopsis
- The study examines the relationship between blood cholesterol levels and coronary heart disease (CHD) risk among over 4 million veterans, exploring claims of a U-shaped association.
- Findings reveal a J-shaped relationship, indicating that while lower cholesterol levels (below 180 mg/dL) show flat CHD mortality risk, higher cholesterol levels significantly increase this risk.
- The results support the lipid hypothesis, suggesting that lower cholesterol is linked to reduced CHD risk, especially highlighting that low cholesterol due to medication does not alter this association.
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