Introduction: Taste sensitivity varies greatly in individuals and depends on many external and metabolic conditions.
Material And Methods: The studied group consisted of healthy, non-smoking 41 women and 40 men, aged 19-29. The volunteers were examined in fasting state and after a high-carbohydrate meal. Taste sensitivity to sweet, salty and sour as well as hedonic response to taste were examined by means of gustometry examination recommended by Polski Komitet Normalizacyjny (Polish Committee for Standardization).
Results: It has been shown that in women the meal did not influence the intensity of sweet taste perception of saccharose solutions or the hedonic response to taste, whereas in men it caused a statistically significant decrease in the intensity of taste perception and in the hedonic response to the sweet taste of suprathreshold saccharose solutions. The meal did not influence the salty taste perception in a statistically significant way, neither in men nor in women. After the meal, the women perceived the sour taste with more intensity than in fasting state, whereas in men such influence was not observed.
Conclusions: 1. The consumption of a high-carbohydrate meal influences the sweet and sour taste perception and the effect is sex-dependent: - in men, both the taste sensitivity to saccharose and the hedonic response to sweet taste were decreased, whereas in women such influence was not observed; - in women, the taste sensitivity to citric acid increased and the hedonic response to sour taste decreased, whereas in men such influence was not observed. 2. There is negative correlation between the intensity of taste perception and the hedonic response to the sweet taste both in men and in women after a high-carbohydrate meal, whereas in fasting state such correlation was not observed.
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Open Heart
January 2025
Center for Congenital Heart Disease Amsterdam Leiden (CAHAL), Leiden University Medical Center, Leiden, Zuid-Holland, Netherlands
Background: Short-term improvements in quality of life (QOL) have been reported in adult congenital heart disease patients with systemic right ventricle (sRV) failure after treatment with sacubitril/valsartan. This study aimed to evaluate the medium-term QOL changes in sRV failure patients treated with sacubitril/valsartan.
Methods: In this single-centre, prospective cohort study, patients with symptomatic sRV failure completed the Netherlands Organisation for Applied Scientific Research/Academic Hospital Leiden Questionnaire for Adult's Health-Related Quality of Life (TAAQOL) at baseline and after starting treatment with sacubitril/valsartan.
The five-item World Health Organization Well-Being Index (WHO-5) is among the most frequently used brief standard measures to assess hedonic well-being. Numerous studies have investigated different facets of its psychometric properties in adult populations. However, whether these results apply to adolescents is uncertain, and only few psychometric studies employed adolescent populations.
View Article and Find Full Text PDFPLoS Biol
January 2025
Department of Biology, University of Fribourg, Fribourg, Switzerland.
Sex Health
January 2025
Mount Sinai Heath System, Center for Transgender Medicine and Surgery, 275 7th Avenue, 15th Floor, New York, NY 10001, USA.
Background In the healthcare setting, transgender patients are often marginalized, face discrimination and have limited access to high-quality gender-affirming care, such as gender-affirming surgery (GAS). As a result, the available data pertaining to GAS are often based on convenience samples, and the majority of published studies in the US are cross-sectional. Transgender people may undergo GAS to align their bodies with their gender identities.
View Article and Find Full Text PDFAJOB Neurosci
January 2025
The Stanley Center for Psychiatric Research, The Broad Institute of MIT, McLean Hospital, Mass General Brigham, and Harvard.
Navigating the demands of translational research requires not only addressing scientific issues, but also managing conflicting sociopolitical, cultural, psychosocial, epistemic, and ethical relationships across diverse communities and academic disciplines. Data and analysis of intensive interviews on these phenomena with researchers are presented here, which led to the co-design of a larger, ongoing study in a neuropsychiatric research community. The results generated a set of hypotheses-particularly regarding conflicts and challenges at the neuroscience-neuroethics interface as experienced by neuroscientists-which have not been fully articulated or examined in the neuroethics literature.
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