A series of pyridopyrazine and pyrimidothiazine derivatives have been synthesized and their activity against FtsZ from Mycobacterium tuberculosis (Mtb) and in vitro antibacterial activity against Mtb H(37)Ra and Mtb H(37)Rv are reported. Certain analogs described herein showed moderate to good inhibitory activity.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3216299 | PMC |
| http://dx.doi.org/10.1016/j.bmc.2011.09.062 | DOI Listing |
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Novel pyridopyrazine and pyrimidothiazine derivatives as FtsZ inhibitors.
Bioorg Med Chem
December 2011
Drug Discovery Division, Southern Research Institute, 2000 Ninth Avenue South, Birmingham, AL 35205, USA.
A series of pyridopyrazine and pyrimidothiazine derivatives have been synthesized and their activity against FtsZ from Mycobacterium tuberculosis (Mtb) and in vitro antibacterial activity against Mtb H(37)Ra and Mtb H(37)Rv are reported. Certain analogs described herein showed moderate to good inhibitory activity.
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