Background: The study was designed to compare the effect of intraincisional vs intraperitoneal infiltration of levobupivacaine 0.25% on post-operative pain in laparoscopic cholecystectomy.
Materials And Methods: This randomised controlled study was carried out on 189 patients who underwent laparoscopic cholecystectomy. Group 1 was the control group and did not receive either intraperitoneal or intraincisional levobupivacaine. Group 2 was assigned to receive local infiltration (intraincisional) of 20 ml solution of levobupivacaine 0.25%, while Group 3 received 20 ml solution of levobupivacaine 0.25% intraperitoneally. Post-operative pain was recorded for 24 hours post-operatively.
Results: Post-operative abdominal pain was significantly lower with intraincisional infiltration of levobupivacaine 0.25% in group 2. This difference was reported from 30 minutes till 24 hours post-operatively. Right shoulder pain showed significantly lower incidence in group 2 and group 3 compared to control group. Although statistically insignificant, shoulder pain was less in group 3 than group 2.
Conclusion: Intraincisional infiltration of levobupivacaine is more effective than intraperitoneal route in controlling post-operative abdominal pain. It decreases the need for rescue analgesia.
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http://dx.doi.org/10.4103/0972-9941.83508 | DOI Listing |
J Pain Res
February 2022
Laboratory of Anesthesia and Critical Care Medicine, National-Local Joint Engineering Research Centre of Translational Medicine of Anesthesiology, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, People's Republic of China.
Purpose: Local anesthetics (LAs) are an important alternative for postoperative analgesia; however, the short duration of LAs limits their use. Thus, we previously developed LL-1, a mixture of QX-OH and levobupivacaine (LB) that produces regional anesthesia for more than 10 h in rats. The aim of this study is to investigate the long-acting mechanism of LL-1 in vivo and in vitro.
View Article and Find Full Text PDFJ Clin Anesth
April 2020
Department of Anaesthesiology, Intensive Care and Pain Management, University Medical Centre Maribor, Ljubljanska ulica 5, 2000 Maribor, Slovenia; Faculty of Medicine, University of Maribor, Taborska ulica 8, 2000 Maribor, Slovenia.
Study Objective: We aimed to determine the magnitude of peri-operative opioid sparing effect when general anesthesia is combined with spinal analgesia for laparoscopic gynecological surgery.
Design: A prospective randomized controlled study; a three-group trial with two comparisons (each intervention group to control).
Setting: Operating room and postoperative recovery area.
Vet Anaesth Analg
January 2020
Dick White Referrals, Station Farm, London Road, Six Mile Bottom, Cambridgeshire, CB8 0UH, UK.
Objective: To compare the perioperative effects and pharmacoeconomics of peripheral nerve blocks (PNBs) versus fentanyl target-controlled infusion (fTCI) in dogs undergoing tibial plateau levelling osteotomy (TPLO).
Study Design: Randomized clinical study.
Animals: A total of 39 dogs undergoing unilateral TPLO.
Folia Med (Plovdiv)
June 2018
School of Pharmacy, RK University, Rajkot-360020, Gujarat,India.
Background: Inappropriate use of drugs and their combinations for analgesics has made it difficult to determine the optimal drug combinations for pain mangement.
Aim: To reduce postoperative pain effectively and safely.
Materials And Methods: Laparotomy was performed in an adult rat under isoflurane anesthesia.
Medicine (Baltimore)
February 2018
Department of Surgery, Kanta-Häme Central Hospital, Hämeenlinna School of Medicine, University of Eastern Finland Department of Anesthesia and Operative Services, Kuopio University Hospital Departments of Gynecology and Oncology, Kuopio University Hospital Department of Surgery, Kuopio University Hospital, Kuopio Admescope, Ltd, Oulu School of Pharmacy, Faculty of Health Sciences, University of Eastern Finland, Kuopio, Finland.
Background: There is a controversy regarding the efficacy of rectus sheath block (RSB). The aim of the present study was to evaluate analgesic efficacy and safety of three different methods of RSB in postoperative pain management after midline laparotomy.
Methods: A prospective, randomized, controlled, open-label clinical trial with 4 parallel groups was conducted in a tertiary care hospital in Finland.
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