Rheological evidence is provided demonstrating that covalent grafting of monodisperse isotactic poly(L-leucine) branches onto linear hyaluronan (HA) polysaccharide chains yields comb-branched HA chains that self-assemble into long-lived physical networks in aqueous solutions driven by hydrophobic interactions between poly(L-leucine) chains. This is in stark contrast to native (unmodified) HA solutions which exhibit no tendency to form long-lived physical networks.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3196612 | PMC |
| http://dx.doi.org/10.1016/j.eurpolymj.2011.07.017 | DOI Listing |
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