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Background: Endocarditis occurs in approximately 10-15% of patients with Staphylococcus aureus bacteremia. Short time to positivity (TTP) in blood culture flasks has been linked to endocarditis in smaller studies. This study evaluated the association between TTP and endocarditis in S.

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Background: Although transcatheter aortic valve implantation (TAVI) is performed for very elderly patients in whom surgical aortic valve replacement (SAVR) poses unacceptably high operative risk, some of these patients are ultimately forced to undergo open surgery when TAVI is complicated by infective endocarditis (IE). To our knowledge, there have been no reports of cases with periannular extension of IE and atrioventricular block successfully treated by antibiotics without valve replacement.

Case Summary: An 80-year-old Japanese man who had undergone TAVI developed IE with loss of consciousness on Day 39 after the procedure.

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Atopic dermatitis is known to be associated with infective endocarditis due to poorer barrier function of the skin, and it has also been reported that patients with atopic dermatitis are at higher risk of mediastinitis after open heart surgery. A 50-year-old man with recurrent episodes of Staphylococcus aureus infection presented to the hospital with a chief complaint of fever and shortness of breath. Close examination revealed mitral regurgitation due to infective endocarditis, and the patient was advised to undergo surgery.

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The case report examines a rare presentation of tricuspid valve infective endocarditis (TVIE) following a septic abortion. A 31-year-old female presented with persistent high-grade fever, chills, and mild vaginal bleeding post medical termination of pregnancy. Despite initial management for septic abortion, including manual evacuation and antibiotics, her symptoms recurred, necessitating further evaluation.

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The antibiotic therapy containing contezolid successfully treated methicillin-sensitive Staphylococcus aureus infective endocarditis accompanied with cerebrovascular complications.

BMC Infect Dis

November 2024

Department of Respiration and Critical Care Medicine, Beijing Anzhen Hospital, Capital Medical University, No. 2, Anzhen Road, Chaoyang District, Beijing, 100029, P.R. China.

Background: Staphylococcus aureus infective endocarditis (IE) in native valves is associated with high mortality rates and is prone to various complications, including embolic strokes, which often result in poor prognoses. Contezolid, a novel oxazolidinone antibiotic, exhibits superior therapeutic efficacy with a reduced risk of hematologic toxicity. However, there are currently no reports on the treatment of methicillin-susceptible Staphylococcus aureus (MSSA) IE accompanied by cerebrovascular complications.

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