This study demonstrates that a more precise prediction of the individual relapse risk in chronic hepatitis C virus genotype 1 infection can be obtained by kinetics of minimal residual viremia at weeks 4, 8, and 12 in combination with levels of baseline viremia. These data may also help to further individualize new protease inhibitor-based triple therapy regimens.
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http://dx.doi.org/10.1093/cid/cir670 | DOI Listing |
In patients with transplant-eligible newly diagnosed multiple myeloma, induction therapy with a quadruplet regimen prior to autologous transplant is the standard of care. The phase III IFM2020-02-MIDAS study (NCT04934475) assessed a minimal residual disease (MRD)-driven consolidation and maintenance strategy following induction with isatuximab, carfilzomib, lenalidomide, and dexamethasone (IsaKRD). Here, we report safety and efficacy outcomes of six 28-day cycles of IsaKRD.
View Article and Find Full Text PDFInt J Gynaecol Obstet
January 2025
Department of Obstetrics and Gynecology, Cerrahpasa Faculty of Medicine, Istanbul University-Cerrahpasa, Istanbul, Turkey.
Objective: Hysteroscopic myomectomy is widely regarded as safe and feasible, although achieving single-session results for larger myomas often requires alternative methods. This study introduces a novel approach: ultrasound-guided myoma extirpation using ring forceps combined with hysteroscopy.
Methods: This retrospective, single-center study includes patients who underwent ultrasound-guided myoma extirpation between 2016 and 2024.
Pract Lab Med
January 2025
Department of Pharmaceutical Sciences, School of Pharmaceutical Science, Babasaheb Bhimrao Ambedkar University, Vidya Vihar, Raebareli Road, 226025, Lucknow, India.
Liquid biopsy is an innovative, minimally invasive diagnostic tool revolutionizing cancer management by enabling the detection and analysis of cancer-related biomarkers from bodily fluids such as blood, urine, or cerebrospinal fluid. Unlike traditional tissue biopsies, which require invasive procedures, liquid biopsy offers a more accessible and repeatable method for tracking cancer progression, detecting early-stage cancers, and monitoring therapeutic responses. The technology primarily focuses on analyzing circulating tumor cells (CTCs), circulating tumor DNA (ctDNA), and other cancer-derived genetic materials.
View Article and Find Full Text PDFJ Food Sci
January 2025
Department of Computer Engineering, Technology Faculty, Selcuk University, Konya, Turkey.
The detection and classification of damage to eggs within the egg industry are of paramount importance for the production of healthy eggs. This study focuses on the automatic identification of cracks and surface damage in chicken eggs using deep learning algorithms. The goal is to enhance egg quality control in the food industry by accurately identifying eggs with physical damage, such as cracks, fractures, or other surface defects, which could compromise their quality.
View Article and Find Full Text PDFInt Dent J
January 2025
Biomaterials Science, Division of Dentistry, School of Medical Sciences, University of Manchester, Manchester, UK.
Introduction And Aims: This study aimed to investigate the efficacy of 3 bleaching methods on stained polymer-based CAD/CAM blocks in terms of surface roughness, hardness stability, discolouration reduction and susceptibility to re-staining following bleaching.
Methods: Two-mm-thick slabs (N = 128) were prepared from CeraSmart (CS), Grandio Blocs (GB), Vita Enamic (VE), and direct resin composite GrandioSO (RC). Coffee-stained specimens (n = 8) were subdivided into bleaching (BL) groups: in-office bleaching (OB), home bleaching (HB), whitening mouthwash (MW), and a control group with 14-day storage in water (CL).
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