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The centenarian blueprint: lessons in defying Parkinson's disease.
J Neural Transm (Vienna)
December 2024
Department of Neurology, Clinical Research Centre, Saiseikai Imabari Hospital, Ehime, 799- 1592, Japan.
Recent advancements in neurology have shifted focus from mere diagnosis to comprehensive management of movement disorders, particularly Parkinson's Disease (PD), which is rapidly increasing in prevalence due to global ageing trends. While age is a key risk factor for PD, centenarians often exhibit a remarkably low prevalence of the disease, presenting an intriguing paradox. This viewpoint explores potential reasons for this low prevalence, drawing on studies from regions with high centenarian populations, known as Blue Zones.
View Article and Find Full Text PDFImproved phosphorus MRSI acquisition through compressed sensing acceleration combined with low-rank reconstruction.
MAGMA
December 2024
Department of Radiology and Medical Informatics, Faculty of Medicine, University of Geneva, Geneva, Switzerland.
Objectives: Phosphorus-31 magnetic resonance spectroscopic imaging (P-MRSI) is a non-invasive tool for assessing cellular high-energy metabolism in-vivo. However, its acquisition suffers from a low sensitivity, which necessitates large voxel sizes or multiple averages to achieve an acceptable signal-to-noise ratio (SNR), resulting in long scan times.
Materials And Methods: To overcome these limitations, we propose an acquisition and reconstruction scheme for FID-MRSI sequences.
Assessing hydrogeochemical facies and Groundwater Quality Index in rapidly urbanizing coastal region: a GIS-based approach with machine learning for enhanced management.
Environ Sci Pollut Res Int
December 2024
Department of Earth Sciences, Indian Institute of Technology Roorkee, Roorkee-247667, Roorkee, Uttarakhand, India.
Groundwater is an essential freshwater source worldwide, but increasing pollution poses risks to its sustainability. This study applied a comprehensive approach to assess hydrogeochemical facies and groundwater quality in Odisha's large low-lying coastal regions. Analysis of 136 samples revealed that sodium (9.
View Article and Find Full Text PDFCausal relationship between dyslipidemia and diabetic neuropathy: a mendelian randomization study.
Metab Brain Dis
December 2024
Department of Neurology, Third Affiliated Clinical Hospital of the Changchun University of Chinese Medicine, Changchun, 130022, China.
Some studies have shown an association between dyslipidemia and diabetic neuropathy (DN), but the genetic association has not been clarified. Therefore, the present study aimed to investigate the genetic causal association between dyslipidemia and DN through a Mendelian randomization (MR) approach. Genetic causal associations between total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL), and high-density lipoprotein cholesterol (HDL) and DN were investigated by MR to provide a basis for the prevention and treatment of DN.
View Article and Find Full Text PDFEnhancing Stability and Catalytic Activity of d-Allulose 3-Epimerase through Multistrategy Computational Design and Cross-Regional Advantageous Mutations.
J Agric Food Chem
December 2024
College of Light Industry and Food Engineering, Guangxi University, 100 Daxue Road, Nanning 530004, Guangxi, China.
d-Allulose 3-epimerase (DAEase) derived from has excellent properties in the catalytic production of d-allulose, a rare sugar with unique biological functions. However, the industrial application of DAEase (Cb-DAEase) for d-allulose production is hindered by its low enzyme activity, poor long-term thermostability, and pH tolerance. In this study, we identified potential noncatalytic residues in Cb-DAEase using methods such as proline substitution, surface charge engineering, and surface residue prediction.
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