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Comparison of the STANDARD M10 . , Xpert . , and BD MAX Cdiff assays as confirmatory tests in a two-step algorithm for diagnosing infection.
Microbiol Spectr
January 2025
Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.
Current guidelines recommend a two-step algorithm rather than relying solely on a single test for diagnosing infection. This algorithm starts with enzyme immunoassay (EIA) for detecting glutamate dehydrogenase (GDH) and toxins A/B, followed by nucleic acid amplification test (NAAT) for GDH-positive but toxin-negative cases. This study compared the performance of three commercial NAATs: the STANDARD M10 , Xpert , and BD MAX Cdiff assays, utilized as confirmatory testing of the two-step algorithm.
View Article and Find Full Text PDFEvaluation of an in-house indirect immunoperoxidase test for detection of antibodies against African swine fever virus.
J Vet Diagn Invest
November 2024
Foreign Animal Disease Diagnostic Laboratory, National Veterinary Services Laboratories, Animal and Plant Health Inspection Service, United States Department of Agriculture, Plum Island Animal Disease Center, Orient Point, NY, USA.
African swine fever (ASF) is a high-consequence transboundary animal disease caused by African swine fever virus (ASFV). Given that vaccines are not widely available, ASFV detection, including by molecular and serologic assays, is paramount to efficacious control and mitigation of ASF. ASFV-specific antibodies can be detected as early as 7-10 d postinfection in infected animals and may persist for several months or longer.
View Article and Find Full Text PDFRetrospective Comparison of Two Aspergillus IgG Enzyme Immunoassays for Diagnosing Pulmonary Aspergillosis.
Med Mycol J
September 2024
Department of Respiratory Medicine and Infectious Diseases, Niigata University Medical & Dental Hospital.
Article Synopsis
- Aspergillus-specific antibodies are used to diagnose allergic bronchopulmonary aspergillosis (ABPA) and chronic pulmonary aspergillosis (CPA), but tests for these were not commonly used in Japan.
- A study evaluated 64 patients with suspected ABPA and CPA using two different enzyme-linked immunosorbent assays (ELISAs) to measure serum Aspergillus IgG levels.
- Results showed that both the Bordier and Bio-Rad kits had high sensitivity and specificity for diagnosing CPA and ABPA, making them good alternatives to the discontinued precipitin test in clinical settings in Japan.
Testing for Blastomycosis, Coccidioidomycosis, and Histoplasmosis at a Major Commercial Laboratory, United States, 2019-2024.
Open Forum Infect Dis
August 2024
Mycotic Diseases Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Article Synopsis
- Blastomycosis, coccidioidomycosis, and histoplasmosis are fungal diseases that mimic pneumonia symptoms, causing diagnostic delays as healthcare providers often don’t consider them initially.
- A study analyzed lab tests from a national lab system between 2019 and 2024, revealing low positive rates for these diseases and highlighting that most tests were ordered by hospitals for histoplasmosis and blastomycosis, while primary care providers primarily ordered coccidioidomycosis tests.
- The findings suggest these fungal infections may be underdiagnosed in primary care and public health settings, signaling a need for greater testing and enhanced surveillance to better manage these diseases.
Comparative Analysis of the Clarus Aspergillus Galactomannan Enzyme Immunoassay Prototype for the Diagnosis of Invasive Pulmonary Aspergillosis in Bronchoalveolar Lavage Fluid.
Mycopathologia
July 2024
Division of Infectious Diseases, Department of Internal Medicine, Medical University of Graz, ECMM Excellence Center, Auenbruggerplatz 15, 8036, Graz, Austria.
Background: Galactomannan (GM) testing using Platelia Aspergillus enzyme immunoassay (Platelia AGM) from bronchoalveolar lavage fluid (BALF) aids in early diagnosis of invasive pulmonary aspergillosis (IPA). Globally, only a minority of laboratories have the capability to perform on-site GM testing, necessitating accessible and affordable alternatives. Hence, we conducted a comparative evaluation of the new clarus Aspergillus GM enzyme immunoassay prototype (clarus AGM prototype) with Platelia AGM using BALF samples.
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