AI Article Synopsis
- Developed a frailty index (FI) combining 31 health-related variables to assess frailty in middle-aged and aged mice.
- Aged mice had significantly higher FI values compared to younger mice, indicating poorer health.
- Findings revealed that myocyte hypertrophy increased and peak contractions decreased in aged mice as FI increased, suggesting that frailty is linked to more severe age-related changes in cardiac cells.
Article Abstract
This study developed an approach to quantify frailty with a frailty index (FI) and investigated whether age-related changes in contractions, calcium transients, and ventricular myocyte length were more prominent in mice with a high FI. The FI combined 31 variables that reflect different aspects of health in middle-aged (∼12 months) and aged (∼30 months) mice of both sexes. Aged animals had a higher FI than younger animals (FI = 0.43 ± 0.03 vs 0.08 ± 0.02, p < .001, n = 12). Myocyte hypertrophy increased by 30%-50% as the FI increased in aged animals. Peak contractions decreased more than threefold from lowest to highest FI values in aged mice (p < .037), but calcium transients were unaffected. Similar results were seen with an FI based on eight noninvasive variables identified as underlying factors. These results show that an FI can be developed for murine models and suggest that age-associated changes in myocytes are more prominent in animals with a high FI.
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| http://dx.doi.org/10.1093/gerona/glr193 | DOI Listing |
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