A strategy to reduce computational demands of genome-wide association studies fitting a mixed model is presented. Improvements are achieved by utilizing a large proportion of calculations that remain constant across the multiple analyses for individual markers involved, with estimates obtained without inverting large matrices.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3249377 | PMC |
| http://dx.doi.org/10.1534/genetics.111.134841 | DOI Listing |
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