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Drug-Silica-Cellulose Ternary Matrix for the Oral Delivery of Cyclosporine A: and evaluation.
Pharm Dev Technol
January 2025
Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Madhavnagar, Manipal - 576104, Karnataka, India.
Purpose: Supersaturated formulations have been widely explored for improving the oral bioavailability of drugs by using mesoporous silica (MS) to generate supersaturation via molecular adsorption; however, this is followed by precipitation. Several precipitation inhibitors (PI) have been explored to prevent precipitation and maintain the drug in solution for a longer period. However, the combined approach of MS and PIs, the impact of MS and Silica, and the loading of high-molecular-weight neutral molecules such as Cyclosporine A (CsA) have not yet been explored.
View Article and Find Full Text PDFRemote -selective C-H bromination of arenes using a recyclable Ru-based aminopropyl bifunctional PMO with robust imidazolium bridges.
Dalton Trans
January 2025
DICATECh, Politecnico di Bari, Bari, I-70125, Italy.
This systematic study delves into the synthesis and characterization of robust bi-functional aminopropyl-tagged periodic mesoporous organosilica with a high loading of small imidazolium bridges in its framework (PrNH@R-PMO-IL, ∼2 mmol g of IL). The materials proved to be a reliable and enduring support for the immobilization of Ru species, demonstrating strong performance and excellent selectivity in the -bromination of various derivatives of 2-phenylpyridine compounds and other heterocycles, showcasing its effectiveness and robust nature. The synthesized materials were thoroughly characterized to determine their structural properties, such as pore size distribution, loading of organic groups, and surface area, using various analytical techniques.
View Article and Find Full Text PDFPeriodic mesoporous organosilica-loaded mincle agonists enhance the immunogenicity of COVID-19 subunit vaccines by dual activation of B cells and dendritic cells.
Acta Biomater
December 2024
National Engineering Laboratory for AIDS Vaccine, School of Life Sciences, Jilin University, Changchun 130012, China; Key Laboratory for Molecular Enzymology and Engineering, the Ministry of Education, School of Life Sciences, Jilin University, Changchun 130012, China. Electronic address:
Effective vaccination is crucial for intervening in the COVID-19 pandemic. However, with the continuous mutation of the SARS-CoV-2, existing vaccines including subunit vaccines cannot effectively prevent virus infections. Hence, there is an urgent need to enhance the immunogenicity of existing vaccines to induce a more potent and durable immune response.
View Article and Find Full Text PDFFRET-based mesoporous organosilica nanoplatforms for and anticancer two-photon photodynamic therapy.
J Mater Chem B
December 2024
ICGM, University of Montpellier, UMR-CNRS 5253, 34293 Montpellier, France.
We report the synthesis of multifunctional periodic mesoporous organosilica nanoparticles (PMO NPs) with substantial two-photon absorption properties and targeting capability for two-photon excitation fluorescence (TPEF) and photodynamic therapy (TPE-PDT). Prepared using an adapted sol-gel synthesis, the nanoplatforms integrated two silylated chromophores in their three-dimensional matrix to maximize non-radiative Förster resonance energy transfer from a high two-photon absorption fluorophore donor to a porphyrin derivative acceptor, leading to an enhanced generation of reactive oxygen species. Combinations of biodegradable and non-biodegradable bis(triethoxysilyl)alkoxysilanes were employed for the synthesis of the NPs, and the corresponding photophysical studies revealed high efficiency levels of FRET.
View Article and Find Full Text PDFSelective Electroreduction of CO2 to CO over Ultrawide Potential Window via Implanting Active Site with Long-Range P Regulation on Periodic Pores.
Angew Chem Int Ed Engl
December 2024
South China University of Technology, School of Chemistry and Chemical Engineering, Wushan St., 510640, Guangzhou, CHINA.
Electroreduction of CO2 to CO represents a highly promising way for artificial carbon cycling, but obtaining high selectivity over a wide potential window remains a challenge due to the sluggish CO generation and diffusion kinetics. Here we report an integration of long-range P modified asymmetrical bismuth atomic site on an ordered macroporous carbon skeleton with mesoporous "wall" (MW-BiN3-POMC) for efficient electroreduction of CO2. In-depth in-situ investigations with theoretical computations reveal that the incorporation of long-range P atom is able to strengthen the orbital interaction between the C 2p of CO2 and Bi 6p, thereby establishing an electronic transport bridge for the activation of CO2 molecule.
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