The authors necessitate careful handling of the dental roots and consider it necessary that indications for the use of pin constructions be widened; they suggest original modifications of such designs and analyze the results of treatment of 176 patients. Examinations of 2,664 adolescents have revealed various dentition defects in 23.2 +/- 1.5%, these defects leading to deformations. Orthodontic treatment and prostheses are necessary to prevent these deformations.
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Behav Brain Sci
January 2025
Department of Life Sciences, University of Trieste, Trieste,
Many motivational constructs are opaque "black boxes," and should be replaced by an explicit account of the underlying psychological mechanisms. The theory of motivational systems has begun to provide such an account. I recently contributed to this tradition with a general architecture of motivation, which connects "energization" and "direction" through the goal-setting activity of emotions, and serves as an evolutionary grounded map of motivational processes.
View Article and Find Full Text PDFRecent Adv Drug Deliv Formul
January 2025
Laboratory of Innovation in Science and Technology - LACITEC, Department of Biophysics and Physiology, Federal University of Piauí, Teresina, Piauí, PI, Brazil.
Duchenne muscular dystrophy is a neuromuscular disease with an overall incidence of between 1 in 5,000 newborn males. Carriers may manifest progressive muscle weakness, resulting from the progressive degeneration of skeletal muscles, generating cardiac and respiratory disorders. Considering the lack of effective treatments, different therapeutic approaches have been developed, such as protein synthesis and extracellular matrix derivatives that can be used to improve muscle regeneration, maintenance, or repair.
View Article and Find Full Text PDFRev Recent Clin Trials
January 2025
Dipartimento Patologia e Cura del Bambino, Regina Margherita AOU Città della Salute e della Scienza di Torino, Presidio Infantile Regina Margherita, Turin, Italy.
Background: Over the past decade, there has been a significant shift from paper-based to digital medical record management, driven largely by advances in digital technology. This transition has led to widespread adoption of Electronic Medical Records (EMRs), with the expectation that paper documentation will soon be fully replaced. In response, the European Medicines Agency's "Guideline on Computerised Systems in Clinical Trials" outlines essential criteria for validated EMR systems to ensure data integrity and security, and sets standards for electronic source documents in clinical trials.
View Article and Find Full Text PDFCureus
December 2024
Department of Prosthodontics and Crown and Bridge, Kothiwal Dental College and Research Centre, Moradabad, IND.
Introduction: Alterations in occlusal relationships in individuals with complete edentulism considerably disrupt the equilibrium of the stomatognathic system. Evaluation of the temporomandibular joint (TMJ) is crucial during the edentulous phase, as it influences both aesthetic and functional outcomes. This investigation sought to assess alterations in condylar positioning one year after the placement of complete dentures in edentulous patients, with additional objectives to examine variations based on sex and side.
View Article and Find Full Text PDFInfect Prev Pract
September 2024
SARS-CoV-2 Sequencing Consortium, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany.
Background: During the SARS-CoV-2 pandemic, dominant viral variants were repeatedly replaced by new variants with altered properties, frequently changing the dynamics of the infection event, as well as the effectiveness of vaccines and therapeutics. SARS-CoV-2 variant monitoring by whole genome sequencing was established at the University Medical Center Mainz, Germany to support patient management during the pandemic.
Methods: SARS-CoV-2 RNA samples from the University Medical Center were analysed weekly with whole genome sequencing.
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