AI Article Synopsis
- Twenty years ago, liver transplantation for hepatitis B was risky due to high recurrence rates and poor outcomes.
- Recent advancements involve using newer antiviral drugs paired with low doses of hepatitis B immunoglobulin (HBIG), leading to better prevention strategies.
- As a result, the recurrence rate of HBV post-transplant has dropped to less than 5%, significantly improving overall outcomes.
Article Abstract
Background: Twenty years ago, liver transplantation for hepatitis B had been a relative contraindication to universal HBV recurrence and poor outcomes. Over the ensuing two decades, there has been refinement of prevention strategies in order to minimize HBV recurrence in the allograft.
Results: Currently, the most efficacious and cost-effective strategies include newer oral antiviral drugs in combination with low doses of hepatitis B immunoglobulin (HBIG). More recently, strategies have been successful in withdrawing HBIG and newer approaches of HBIG avoidance are currently under development.
Conclusion: Thus, 20 years afterward, HBV recurrence is <5% and outcomes following liver transplantation are excellent.
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| http://dx.doi.org/10.1007/s12072-011-9293-8 | DOI Listing |
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