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Lubricating effect of sialomucin and hyaluronan on pleural mesothelium. | LitMetric

AI Article Synopsis

  • - The coefficient of kinetic friction (μ) between rabbit pleura increases significantly after blotting the mesothelial surface with filter paper, but can be somewhat reduced by wetting with Ringer solution.
  • - Testing showed that adding sialomucin or hyaluronan solutions after blotting further decreased μ to levels similar to pre-blotting values, indicating these substances are crucial for reducing friction.
  • - Electron microscopy revealed that blotting removed microvilli from the mesothelium, highlighting the loss of essential lubricating macromolecules like sialomucin and hyaluronan, which affects pleural lubrication.

Article Abstract

Coefficient of kinetic friction (μ) between rabbit visceral and parietal pleura, sliding in vitro at physiological velocities and load, increases markedly after blotting mesothelial surface with filter paper; this increase is only partially reduced by wetting blotted mesothelium with Ringer solution. Given that mesothelial surface is covered by a thick coat with sialomucin and hyaluronan, we tested whether addition of sialomucin or hyaluronan solution after blotting lowers μ more than Ringer alone. Actually, these macromolecules lowered μ more than Ringer, so that μ was no longer significantly higher than its preblotting value. Moreover, Ringer addition, after washout of macromolecule solution, increased μ, in line with their dilution. These findings indicate that mesothelial blotting removes part of these molecules from the coat covering mesothelial surface, and their relevance for pleural lubrication. Transmission electron micrographs of pleural specimens after mesothelial blotting showed that microvilli were partially or largely removed from mesothelium, consistent with a substantial loss of macromolecules normally entrapped among them.

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Source
http://dx.doi.org/10.1016/j.resp.2011.10.006DOI Listing

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