GalR1 and GalR2 represent unique pharmacological targets for treatment of seizures and epilepsy. A novel series of 2,4,6-triaminopyrimidine derivatives were synthesized and found to have sub-micromolar affinity for GalR2. Optimization of a series of 2,4,6-triaminopyrimidines led to the discovery of several analogs with IC50 values ranging from 0.3 to 1 μM.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3278223 | PMC |
| http://dx.doi.org/10.1016/j.bmcl.2011.09.033 | DOI Listing |
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